Whole chromosome instability and cancer: a complex relationship
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerThe CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsCAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationA Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.The c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cellsReduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutationCdc20 is critical for meiosis I and fertility of female miceAging-Induced Stem Cell Mutations as Drivers for Disease and CancerCHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.Reprogramming to pluripotency can conceal somatic cell chromosomal instabilityUSP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesisOverexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemiaUp-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsChromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeresOverexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.Senescent cells: a novel therapeutic target for aging and age-related diseasesWhole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.Experimental study on effect of simulated microgravity on structural chromosome instability of human peripheral blood lymphocytes.Mechanisms and consequences of aneuploidy and chromosome instability in the aging brainMitotic chromosomal instability and cancer: mouse modelling of the human disease.The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Chromosome missegregation causes colon cancer by APC loss of heterozygosity.Chromosomal alterations in exfoliated urothelial cells from bladder cancer cases and healthy men: a prospective screening studyMarked aneuploidy and loss of multiple chromosomes are common in autosomal mutants isolated from normal mouse kidney epithelium.Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiationBub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationCorrelation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival.Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.Integration of Network Biology and Imaging to Study Cancer Phenotypes and Responses.Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice.Topoisomerase IIα in chromosome instability and personalized cancer therapy.Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability modelBub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ MiceAneuploidy in health, disease, and aging.
P2860
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P2860
Whole chromosome instability and cancer: a complex relationship
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Whole chromosome instability and cancer: a complex relationship
@en
type
label
Whole chromosome instability and cancer: a complex relationship
@en
prefLabel
Whole chromosome instability and cancer: a complex relationship
@en
P2093
P2860
P1433
P1476
Whole chromosome instability and cancer: a complex relationship
@en
P2093
Jan M van Deursen
Janine H van Ree
Robin M Ricke
P2860
P304
P356
10.1016/J.TIG.2008.07.002
P577
2008-07-31T00:00:00Z