Molecular genetics of multiple endocrine neoplasia types 1 and 2.
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Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) proteinStructural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.Role of lncRNAs in Cellular AgingGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumorsMenin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemiaMolecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.The anti-hypertensive drug prazosin induces apoptosis in the medullary thyroid carcinoma cell line TT.Menin enhances c-Myc-mediated transcription to promote cancer progressionAnti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells.Menin/PRMT5/hedgehog signaling: a potential target for the treatment of multiple endocrine neoplasia type 1 tumors.Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancerFBP1 Is an Interacting Partner of Menin.Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2.Clinical and molecular genetics of parathyroid neoplasmsBeckwith-Wiedemann and IMAGe syndromes: two very different diseases caused by mutations on the same geneAntitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer modelsReversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.BAY 43-9006 inhibition of oncogenic RET mutants.Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene.The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studiesChallenges and opportunities in targeting the menin-MLL interaction.Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutationsTotal parathyroidectomy in a large cohort of cases with hyperparathyroidism associated with multiple endocrine neoplasia type 1: experience from a single academic center.Biochemical, bone and renal patterns in hyperparathyroidism associated with multiple endocrine neoplasia type 1.The current strategy for managing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1.PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target.Pathogenetic mechanisms in thyroid follicular-cell neoplasia.Histologic and Molecular Profile of Pediatric Insulinomas: Evidence of a Paternal Parent-of-Origin EffectThe transcriptome that mediates increased cyclic adenosine monophosphate signaling in PRKAR1A defects and other settings.Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populationsA differential diagnosis of inherited endocrine tumors and their tumor counterpartsCorrelation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas.A patient with MEN1 typical features and MEN2-like features.In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9.
P2860
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P2860
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
@ast
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
@en
type
label
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
@ast
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
@en
prefLabel
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
@ast
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
@en
P2860
P356
P1476
Molecular genetics of multiple endocrine neoplasia types 1 and 2.
@en
P2093
Stephen J Marx
P2860
P2888
P304
P356
10.1038/NRC1610
P407
P577
2005-05-01T00:00:00Z