Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles
about
Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in AplysiaHuntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitorsRrs1 is involved in endoplasmic reticulum stress response in Huntington diseaseHuntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transportHuntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicityClioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factorInactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.GRASPs in Golgi Structure and FunctionGolgi fragmentation in Alzheimer's diseaseThe choreography of neuroinflammation in Huntington's diseaseIron dysregulation in Huntington's diseaseGolgi defects enhance APP amyloidogenic processing in Alzheimer's diseaseA huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease.Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR ApproachMelatonin in Alzheimer's disease and other neurodegenerative disordersNormal huntingtin function: an alternative approach to Huntington's diseaseHuntington's diseaseUnbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolismScalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinMutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitroRedox proteomics in selected neurodegenerative disorders: from its infancy to future applications.Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.A neuroprotective phase precedes striatal degeneration upon nucleolar stress.Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.The role of iron in brain ageing and neurodegenerative disorders.Role of iron in neurodegenerative diseases.Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting.Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.MRI T2 Hypointensities in basal ganglia of premanifest Huntington's diseaseHuntington disease models and human neuropathology: similarities and differencesAltered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtinWild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptorsDepression in patients with Huntington disease correlates with alterations of the brain stem raphe depicted by transcranial sonographyHD CAG-correlated gene expression changes support a simple dominant gain of function.Clinical and research advances in Huntington's disease.Iron in neurodegenerative disorders.The long history of iron in the Universe and in health and disease.
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P2860
Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles
description
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im November 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/11/22)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/11/22)
@nl
наукова стаття, опублікована в листопаді 2000
@uk
مقالة علمية (نشرت في 22-11-2000)
@ar
name
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@ast
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@en
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@nl
type
label
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@ast
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@en
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@nl
prefLabel
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@ast
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@en
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@nl
P2093
P356
P1476
Huntingtin: an iron-regulated ...... ear and perinuclear organelles
@en
P2093
A. Auerbach
F. Persichetti
F. Trettel
L. A. Passani
M. E. MacDonald
P. Hilditch-Maguire
P304
P356
10.1093/HMG/9.19.2789
P577
2000-11-22T00:00:00Z