Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission
about
Modulation of neuronal signal transduction and memory formation by synaptic zincThe impact of human hyperekplexia mutations on glycine receptor structure and functionStructure of the zinc transporter YiiPTonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission.Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunitGlycine receptor mouse mutants: model systems for human hyperekplexiaMutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivoSynaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?Allosteric modulation of glycine receptors.The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Zinc enhances ethanol modulation of the alpha1 glycine receptor.pH-dependent inhibition of kainate receptors by zinc.Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsPulsed electron spin resonance resolves the coordination site of Cu²(+) ions in α1-glycine receptorZinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memoryCharacterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory resultsGeneration of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits.Inhibitory glycine receptors: an update.Fast synaptic inhibition in spinal sensory processing and pain control.Allosteric modulation of ATP-gated P2X receptor channelsSupralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.Chelation of neurotoxic zinc levels does not improve neurobehavioral outcome after traumatic brain injury.Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2 receptors.Genetic dissection of testis weight in a mouse strain having an extremely large testis: major testis weight determinants are autosomal rather than Y-linked on the basis of comprehensive analyses in Y-chromosome consomic strains.Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia.Is zinc a neuromodulator?The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μMPropofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activationThe GLRA1 missense mutation W170S associates lack of Zn2+ potentiation with human hyperekplexia.Zinc homeostasis and signaling in health and diseases: Zinc signaling.New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability.The cancer chemotherapeutic agent paclitaxel (Taxol) reduces hippocampal neurogenesis via down-regulation of vesicular zinc.Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex.
P2860
Q21090473-07EA91FC-F62F-461B-9DF0-48B53A660529Q26830661-303338FB-FC59-4218-BDF1-10F62EBE78E0Q27647503-0953A03C-5236-4F3B-85E3-9D32FE6D0CEBQ30375424-2D0AE3B2-D743-4C1F-8CC6-043AAB51C7C0Q30407440-822AD1C4-2828-4F03-9222-C09CE9F3FD3DQ30426940-C72892A5-873F-473F-9F17-50F1CC4004E2Q30443658-AEA8CB21-1D66-4839-A11A-9E6A7823B368Q30446735-467B0A2E-2619-42CE-9D61-E857D42F0A38Q30450700-1CE45934-05B3-4D8D-A10A-D91064249D47Q30461478-BDD9972B-BED3-4E8D-9628-C11F8C4A82FBQ30464018-D035D8B2-C84D-446A-B829-4B8CFCF86A5AQ30486732-968CF3EA-2221-4A4E-8D29-A48832D16A5BQ33830483-4544038A-8B75-4B33-A61A-783B5D4C19A8Q33909609-D9139050-E2AA-434E-8E6A-31F334F92FD5Q33975173-9AC2BD04-EE92-4BF4-8F71-468EA08D88E3Q34202131-3A3D1772-A601-4A80-AAD7-4CDC35E7BDA3Q34602744-E9EEDC29-917D-4990-99DA-CE164DC1FA1CQ35688558-94032DB2-C8D9-4EAC-BA40-801598914434Q36088170-504DAE33-ABD5-4239-9EBC-A8A85BF0260DQ36396544-BDCB6162-DF7B-47E9-8F57-04E7A42C7D6FQ36418772-21131A52-433E-4AF1-B2E2-A4B41C6B4CF8Q36661675-7D772F07-AB3D-4D95-962E-F065614E516BQ36825825-D262F5D0-60AD-4114-AADF-A64A668EF21FQ36858675-A0796739-BE3A-4F97-9A2D-39796E3877DDQ36867735-62B978CC-48D4-406A-9805-575E8CB8846BQ36951788-470AF382-27F3-45E2-B310-CE827ABE680CQ37040020-CAE3FE73-618F-4C43-A5AF-56962CA6C081Q37098960-1BB52E58-FCCB-4AF5-A9F2-18AEE8A070AFQ37163735-30FE5346-D1BF-46E6-98E6-4D3E8DE42EFDQ37273287-C99F4ED3-6268-4602-95E3-C44FE3A0C30AQ37334375-4A0583BB-9DA9-44CC-95D7-77CEC69EDACDQ37415815-A63A29DE-DF38-4BF4-A802-F18BE2FE46EDQ37887564-66D1F93B-B139-4EB6-B223-3155FA898DD8Q37893463-24D9AB02-5626-49C1-AC0F-3C802F51FF00Q38530500-2F1F4B47-9508-4CCC-ADD8-C506A9C5E0E1Q39287341-5D5B9E04-FB4F-4C13-84C3-5A58048BECCFQ39937407-CD73A00F-0C0B-4705-9EFC-5188128C9BD4Q39956396-511387E5-9D3D-40B6-8311-2FE417B6150FQ41718205-11EB4B1C-466A-4B96-8940-69D86516FFF1Q41828103-C345105C-F5DD-442C-A73D-00C39A726FD2
P2860
Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission
description
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im November 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/11/22)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/11/22)
@nl
наукова стаття, опублікована в листопаді 2006
@uk
مقالة علمية (نشرت في 22-11-2006)
@ar
name
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@ast
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@en
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@nl
type
label
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@ast
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@en
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@nl
prefLabel
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@ast
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@en
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@nl
P2093
P3181
P1433
P1476
Hyperekplexia phenotype of gly ...... glycinergic neurotransmission
@en
P2093
A Tobias Latal
Bodo Laube
Heinrich Betz
Joanna Grudzinska
Klaus Hirzel
Mathias W Seeliger
Ulrike Müller
P304
P3181
P356
10.1016/J.NEURON.2006.09.035
P407
P577
2006-11-01T00:00:00Z