A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
about
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 moduleImpaired spleen formation perturbs morphogenesis of the gastric lobe of the pancreasThe Mohawk homeobox gene is a critical regulator of tendon differentiationRole of the homeodomain transcription factor Bapx1 in mouse distal stomach developmentHypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotypeOtt1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleenScapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.Control of pelvic girdle development by genes of the Pbx family and Emx2.Identification of novel genes and transcription factors involved in spleen, thymus and immunological development and function.Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract.PBX1 is a favorable prognostic biomarker as it modulates 13-cis retinoic acid-mediated differentiation in neuroblastoma.Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.The TALE face of Hox proteins in animal evolutionThe atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity.Tcf21 regulates the specification and maturation of proepicardial cells.Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors.Pbx1 is required for adult subventricular zone neurogenesis.Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract.Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.Left-right asymmetry in gut development: what happens next?Molecular insights into the origin of the Hox-TALE patterning system.Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.Glimpse into Hox and tale regulation of cell differentiation and reprogramming.Divergence of Vascular Specification in Visceral Lymphoid Organs-Genetic Determinants and Differentiation Checkpoints.Coelomic epithelium-derived cells in visceral morphogenesis.PBX1 attributes as a determinant of connexin 32 downregulation in Helicobacter pylori-related gastric carcinogenesis.Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.PBX1 as Pioneer Factor: A Case Still Open.Targeting HOX/PBX dimers in cancer.Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development.p160 Myb-binding protein interacts with Prep1 and inhibits its transcriptional activity.Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels.TLX1/HOX11 transcription factor inhibits differentiation and promotes a non-haemopoietic phenotype in murine bone marrow cells.Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.
P2860
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P248
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P2860
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
description
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Juli 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/07/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/07/01)
@nl
наукова стаття, опублікована в липні 2005
@uk
مقالة علمية (نشرت في يوليو 2005)
@ar
name
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@ast
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@en
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@nl
type
label
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@ast
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@en
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@nl
prefLabel
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@ast
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@en
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@nl
P2093
P356
P1433
P1476
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
@en
P2093
Andrea Brendolan
Elisabetta Ferretti
Francesco Blasi
Kelvin Moses
Licia Selleri
Michael L. Cleary
Susan Quaggin
Valentina Salsi
P304
P356
10.1242/DEV.01884
P407
P577
2005-07-01T00:00:00Z