Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.
about
Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cellsTranscription factor-mediated reprogramming toward hematopoietic stem cellsAtaxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discoveryCorepressor Rcor1 is essential for murine erythropoiesisInternal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic CellsTgif1 regulates quiescence and self-renewal of hematopoietic stem cellsTargeted resequencing and analysis of the Diamond-Blackfan anemia disease locus RPS19.Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.Essential role for Pbx1 in corneal morphogenesis.Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.Computational integration of homolog and pathway gene module expression reveals general stemness signatures.Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism.Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors.Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cellsc-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis.TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier.Dnmt3a is essential for hematopoietic stem cell differentiation.Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesisExpansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution abilityTranscription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1MLL becomes functional through intra-molecular interaction not by proteolytic processingPrdm16 is a physiologic regulator of hematopoietic stem cells.Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.Computational promoter modeling identifies the modes of transcriptional regulation in hematopoietic stem cellsThe deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesisThe critical role of agrin in the hematopoietic stem cell niche.Return to youth with Sox17.Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitorsPrep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway.ΔNp63α promotes cellular quiescence via induction and activation of Notch3.Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.CREB and leukemogenesis.Homeobox genes in obsessive-compulsive disorder.Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice.Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cellsFIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
P2860
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P2860
Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Pbx1 regulates self-renewal of ...... maintaining their quiescence.
@en
type
label
Pbx1 regulates self-renewal of ...... maintaining their quiescence.
@en
prefLabel
Pbx1 regulates self-renewal of ...... maintaining their quiescence.
@en
P2093
P2860
P1433
P1476
Pbx1 regulates self-renewal of ...... y maintaining their quiescence
@en
P2093
Mark J Murphy
Michael L Cleary
P2860
P304
P356
10.1016/J.STEM.2008.03.004
P407
P577
2008-05-01T00:00:00Z