Heparanase induces Akt phosphorylation via a lipid raft receptor
about
Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VIIPG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma modelHeparanase promotes engraftment and prevents graft versus host disease in stem cell transplantationA novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.Heparanase cooperates with Ras to drive breast and skin tumorigenesisTumorigenic and adhesive properties of heparanase.Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.Allele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma.Pre-clinical and clinical significance of heparanase in Ewing's sarcoma.Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancerThe endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymesCharacterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependenceHeparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathwayImpact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applicationsStructure-function approach identifies a COOH-terminal domain that mediates heparanase signaling.Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression.Heparanase: one molecule with multiple functions in cancer progression.Heparanase: busy at the cell surface.The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics.Two heparanase splicing variants with distinct properties are necessary in early Xenopus development.Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14.Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats.
P2860
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P2860
Heparanase induces Akt phosphorylation via a lipid raft receptor
description
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Oktober 2007 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2007/10/05)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/10/05)
@nl
наукова стаття, опублікована в жовтні 2007
@uk
مقالة علمية (نشرت في 5-10-2007)
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name
Heparanase induces Akt phosphorylation via a lipid raft receptor
@ast
Heparanase induces Akt phosphorylation via a lipid raft receptor
@en
Heparanase induces Akt phosphorylation via a lipid raft receptor
@nl
type
label
Heparanase induces Akt phosphorylation via a lipid raft receptor
@ast
Heparanase induces Akt phosphorylation via a lipid raft receptor
@en
Heparanase induces Akt phosphorylation via a lipid raft receptor
@nl
prefLabel
Heparanase induces Akt phosphorylation via a lipid raft receptor
@ast
Heparanase induces Akt phosphorylation via a lipid raft receptor
@en
Heparanase induces Akt phosphorylation via a lipid raft receptor
@nl
P2093
P2860
P1476
Heparanase induces Akt phosphorylation via a lipid raft receptor
@en
P2093
Olga Ben-Zaken
Svetlana Gingis-Velitski
P2860
P304
P356
10.1016/J.BBRC.2007.06.188
P407
P577
2007-10-05T00:00:00Z