Aurora A is essential for early embryonic development and tumor suppression
about
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrestNon-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell DivisionAurora A's Functions During Mitotic Exit: The Guess Who GameAurora kinase A in gastrointestinal cancers: time to targetBPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cellsConditional Aurora A deficiency differentially affects early mouse embryo patterningAurora kinase-A deficiency during skin development impairs cell division and stratificationIdentification of genes that are essential to restrict genome duplication to once per cell divisionAurora kinases: novel therapy targets in cancersSmall cell lung cancer: where do we go from here?Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.The aurora kinases in cell cycle and leukemiaPTEN interacts with histone H1 and controls chromatin condensation.Sorting out functions of sirtuins in cancerAurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model.Small cell lung cancer: will recent progress lead to improved outcomes?Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.Regulation of embryonic and induced pluripotency by aurora kinase-p53 signalingMitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.Rho GTPase-independent regulation of mitotic progression by the RhoGEF Net1The potential role of Aurora kinase inhibitors in haematological malignancies.Links between DNA Replication, Stem Cells and Cancer.Cell cycle proteins as promising targets in cancer therapyAurora kinase inhibitor patents and agents in clinical testing: an update (2009-10).ENMD-2076 for hematological malignancies.The cancer biology of whole-chromosome instability.A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.Clinical Development of Anti-mitotic Drugs in Cancer.Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias.Aurora kinase A is essential for correct chromosome segregation in mouse zygote.Meta-analysis of the expression of the mitosis-related gene Fam83D.Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities.The balance of Polo-like kinase 1 in tumorigenesis.Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death.A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.NQO1 prevents radiation-induced aneuploidy by interacting with Aurora-A.
P2860
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P2860
Aurora A is essential for early embryonic development and tumor suppression
description
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
@ast
im November 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/11/14)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/11/14)
@nl
наукова стаття, опублікована в листопаді 2008
@uk
name
Aurora A is essential for early embryonic development and tumor suppression
@ast
Aurora A is essential for early embryonic development and tumor suppression
@en
Aurora A is essential for early embryonic development and tumor suppression
@nl
type
label
Aurora A is essential for early embryonic development and tumor suppression
@ast
Aurora A is essential for early embryonic development and tumor suppression
@en
Aurora A is essential for early embryonic development and tumor suppression
@nl
prefLabel
Aurora A is essential for early embryonic development and tumor suppression
@ast
Aurora A is essential for early embryonic development and tumor suppression
@en
Aurora A is essential for early embryonic development and tumor suppression
@nl
P2093
P2860
P3181
P356
P1476
Aurora A is essential for early embryonic development and tumor suppression
@en
P2093
Jamie L. Wood
Junjie Chen
Katherine Minter-Dykhouse
Thomas L. Saunders
Xiaochun Yu
P2860
P304
31785–31790
P3181
P356
10.1074/JBC.M805880200
P407
P577
2008-11-14T00:00:00Z