Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas - Wikidata - awgldk - TriplyDB

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

http://www.wikidata.org/entity/Q28592004

about

A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression Wnt signaling: the good and the bad Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes Mouse models of liver cancer: Progress and recommendations Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish Mouse models in liver cancer research: A review of current literature Genetic alterations in hepatocellular carcinoma: An update Aberrant regulation of Wnt signaling in hepatocellular carcinoma PDGFRα in liver pathophysiology: emerging roles in development, regeneration, fibrosis, and cancer β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis Tumor suppressor and hepatocellular carcinoma Dickkopfs and Wnt/β-catenin signalling in liver cancer Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo Constitutive turnover of cyclin E by Cul3 maintains quiescence Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation.miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis.Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.Molecular genetics of hepatocellular neoplasia.Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis.Expression of Wnt-5a and β-catenin in primary hepatocellular carcinoma.Role of Wnt/β-catenin signaling in liver metabolism and cancer Cancer gene discovery in hepatocellular carcinoma Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis.MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6.The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.Experimental models of hepatocellular carcinoma c-Myc and transforming growth factor α enhance the development of hepatic lesions due to mutant β-catenin in transgenic mice Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad.Histone Demethylases in Colon Cancer.Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].Effect of mutant β-catenin on liver growth homeostasis and hepatocarcinogenesis in transgenic mice Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC.

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P2860

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

http://www.wikidata.org/entity/Q28592004

description

2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

article publié dans les Procee ...... f the United States of America

@fr

artículu científicu espublizáu en 2004

@ast

im Dezember 2004 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2004/12/07)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd op 2004/12/07)

@nl

наукова стаття, опублікована в грудні 2004

@uk

name

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@ast

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@en

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@nl

type

label

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@ast

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@en

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@nl

prefLabel

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@ast

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@en

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@nl

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PNAS.0404761101

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Liver-targeted disruption of A ...... s to hepatocellular carcinomas

@en

P2093

A. Kahn

http://www.w3.org/2001/XMLSchema#string

C. Godard

http://www.w3.org/2001/XMLSchema#string

C. Perret

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G. Hamard

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M. Giovannini

http://www.w3.org/2001/XMLSchema#string

M. Niwa-Kawakita

http://www.w3.org/2001/XMLSchema#string

S. Colnot

http://www.w3.org/2001/XMLSchema#string

T. Decaens

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of c-MYC as a target of the APC pathway

Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

Caught up in a Wnt storm: Wnt signaling in cancer

Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.

The p53 tumor suppressor gene: from molecular biology to clinical investigation.

Genetics of hepatocellular carcinoma.

Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver.

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17216–17221

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scholarly article

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2705923

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10.1073/PNAS.0404761101

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49

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101

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2004-12-07T00:00:00Z

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8162996

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15563600

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Adenomatous polyposis coli protein

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535370

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