Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth
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Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survivalStructure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type foldReduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activationHepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cellsThe crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition.Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.Membrane-anchored serine proteases in vertebrate cell and developmental biologyPurification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.Membrane-anchored serine proteases in health and disease.Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality.Matriptase: a culprit in cancer?Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).The matriptase-prostasin proteolytic cascade in epithelial development and pathology.TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.The basal chorionic trophoblast cell layer: An emerging coordinator of placenta development.The role of type II transmembrane serine protease-mediated signaling in cancer.Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases.Down-regulation of HAI-1 is associated with poor-differentiation status of colorectal cancer.Roles of Kunitz domains in the anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells.The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.Recombinant hepatocyte growth factor activator inhibitor 1: expression in Drosophila S2 cells, purification and crystallization.Hepatocyte growth factor activator inhibitor type 1 inhibits protease activity and proteolytic activation of human airway trypsin-like protease.Matriptase, Protease-activated Receptor 2, and Idiopathic Pulmonary Fibrosis. Further Evidence for Signaling Pathway Redundancy in this Difficult-to-Treat Disease?Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.
P2860
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P2860
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth
description
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im März 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/03/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/03/01)
@nl
наукова стаття, опублікована в березні 2007
@uk
مقالة علمية (نشرت في مارس 2007)
@ar
name
Hepatocyte growth factor activ ...... developing placental labyrinth
@ast
Hepatocyte growth factor activ ...... developing placental labyrinth
@en
Hepatocyte growth factor activ ...... developing placental labyrinth
@nl
type
label
Hepatocyte growth factor activ ...... developing placental labyrinth
@ast
Hepatocyte growth factor activ ...... developing placental labyrinth
@en
Hepatocyte growth factor activ ...... developing placental labyrinth
@nl
prefLabel
Hepatocyte growth factor activ ...... developing placental labyrinth
@ast
Hepatocyte growth factor activ ...... developing placental labyrinth
@en
Hepatocyte growth factor activ ...... developing placental labyrinth
@nl
P2093
P1476
Hepatocyte growth factor activ ...... developing placental labyrinth
@en
P2093
Daniel Kirchhofer
Deanna Grant
Franklin Peale
Linda Rangell
P304
P356
10.1016/J.YDBIO.2006.11.005
P407
P50
P577
2006-11-10T00:00:00Z