PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling
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PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402Mitochondrial dysfunction in Parkinson's diseaseThe Progress of Induced Pluripotent Stem Cells as Models of Parkinson's DiseaseUbiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentPivotal Importance of STAT3 in Protecting the Heart from Acute and Chronic Stress: New Advancement and Unresolved IssuesSystems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor SystemMitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infectionPINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrixDysregulation of autophagy and mitochondrial function in Parkinson's diseaseParkinson's disease: animal models and dopaminergic cell vulnerabilityBeyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial healthCardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiencyAccessory subunits are integral for assembly and function of human mitochondrial complex I.Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia.Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damageDrp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivoMitochondrial Diseases Part I: mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors.The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes.Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases.Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo.The Organization of Mitochondrial Quality Control and Life Cycle in the Nervous System In Vivo in the Absence of PINK1.Differential Expression of Genes that Control Respiration Contribute to Thermal Adaptation in Redband Trout (Oncorhynchus mykiss gairdneri).Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivoNatural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues.The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationMitochondrial ROS Produced via Reverse Electron Transport Extend Animal LifespanDeletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.Rotenone-induced energy stress decompensated in ventral mesocerebrum is associated with Parkinsonism progression in ratsMiro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons.Chemical modifications of respiratory complex I for structural and functional studies.
P2860
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P2860
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling
description
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 2014
@ast
im April 2014 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2014/04/11)
@sk
vědecký článek publikovaný v roce 2014
@cs
wetenschappelijk artikel (gepubliceerd op 2014/04/11)
@nl
наукова стаття, опублікована у квітні 2014
@uk
name
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@ast
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@en
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@nl
type
label
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@ast
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@en
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@nl
prefLabel
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@ast
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@en
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
PINK1 loss-of-function mutatio ...... NdufA10 ubiquinone uncoupling
@en
P2093
Anne Grünewald
Dominik Haddad
Jef Swerts
Katleen Craessaerts
Lut Overbergh
Philip Seibler
Sven Vilain
Vanessa A. Morais
P2860
P304
P356
10.1126/SCIENCE.1249161
P407
P577
2014-04-11T00:00:00Z