Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
about
Update on the Kelch-like (KLHL) gene familyUbiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathwayThe GI-GPx gene is a target for Nrf2Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cellsKeap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activitySequence and structural analysis of BTB domain proteinsRole of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanismConcerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damageRegulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant GenesEvidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosisDifferent Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress ResponseRecent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative DiseasesEmerging roles of Nrf2 signal in non-small cell lung cancerSerotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's DiseaseDual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanismsDifferential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cellsRedox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degronFetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated proteinCrystal structure of the Kelch domain of human Keap1Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung FibrosisPGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondriaStress-activated cap'n'collar transcription factors in aging and human diseaseSmall molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemEffect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative responseBasic principles and emerging concepts in the redox control of transcription factorsNrf2 signaling and cell survivalMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseEmerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotectionEffects of atrazine on the oxidative damage of kidney in Wister ratsNrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signalingActinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathwayNrf2:INrf2 (Keap1) signaling in oxidative stressOxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducersProspective type 1 and type 2 disulfides of Keap1 protein.The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
P2860
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P2860
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/02/17)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/02/17)
@nl
наукова стаття, опублікована в лютому 2004
@uk
name
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@ast
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@en
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@nl
type
label
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@ast
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@en
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@nl
prefLabel
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@ast
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@en
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@nl
P2093
P2860
P3181
P356
P1476
Scaffolding of Keap1 to the ac ...... f cytoprotective phase 2 genes
@en
P2093
Akira Kobayashi
Masayuki Yamamoto
Moon-Il Kang
Nobunao Wakabayashi
Sang-Geon Kim
P2860
P304
P3181
P356
10.1073/PNAS.0308347100
P407
P577
2004-02-17T00:00:00Z