Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
about
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexDisruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentA novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulinThe tuberous sclerosis complexThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthPotential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathwayTurnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosisBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisRegulation of mTORC1 by PI3K signalingThe discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug designCell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin BPam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complexAssociation of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growthThe TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteinsGenetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppressionNon-canonical functions of the tuberous sclerosis complex-Rheb signalling axisActivation of a metabolic gene regulatory network downstream of mTOR complex 1TOR signaling.Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.Missense mutations to the TSC1 gene cause tuberous sclerosis complex.Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2Molecular genetic basis of tuberous sclerosis complex: from bench to bedside.Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.Tor signalling in bugs, brain and brawn.Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor.Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes.PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTORSignaling control of mRNA translation in cancer pathogenesis.Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex.The tuberous sclerosis complex genes in tumor development.
P2860
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P2860
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
description
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Oktober 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/10/28)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/10/28)
@nl
наукова стаття, опублікована в жовтні 2002
@uk
مقالة علمية (نشرت في 28-10-2002)
@ar
name
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@ast
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@en
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@nl
type
label
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@ast
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@en
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@nl
prefLabel
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@ast
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@en
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@nl
P2093
P2860
P1476
Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent
@en
P2093
Anja Jaeschke
George Thomas
Joerg Hartkamp
Julian Sampson
Masao Saitoh
Richard Lamb
Takahiro Nobukuni
Wendy Roworth
P2860
P304
P356
10.1083/JCB.JCB.200206108
P407
P577
2002-10-28T00:00:00Z