Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent - Wikidata - awgldk - TriplyDB

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

http://www.wikidata.org/entity/Q28593855

about

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3 Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin The tuberous sclerosis complex The TSC1-TSC2 complex: a molecular switchboard controlling cell growth Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis Regulation of mTORC1 by PI3K signaling The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38 Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis Activation of a metabolic gene regulatory network downstream of mTOR complex 1 TOR signaling.Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.Missense mutations to the TSC1 gene cause tuberous sclerosis complex.Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2 Molecular genetic basis of tuberous sclerosis complex: from bench to bedside.Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.Tor signalling in bugs, brain and brawn.Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor.Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes.PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR Signaling control of mRNA translation in cancer pathogenesis.Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex.The tuberous sclerosis complex genes in tumor development.

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

http://www.wikidata.org/entity/Q28593855

description

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2002

@ast

im Oktober 2002 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2002/10/28)

@sk

vědecký článek publikovaný v roce 2002

@cs

wetenschappelijk artikel (gepubliceerd op 2002/10/28)

@nl

наукова стаття, опублікована в жовтні 2002

@uk

مقالة علمية (نشرت في 28-10-2002)

@ar

name

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@ast

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@en

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@nl

type

label

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@ast

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@en

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@nl

prefLabel

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@ast

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@en

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@nl

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JCB.JCB.200206108

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Journal of Cell Biology

P1476

Tuberous sclerosis complex tum ...... -OH kinase is mTOR independent

@en

P2093

Anja Jaeschke

http://www.w3.org/2001/XMLSchema#string

George Thomas

http://www.w3.org/2001/XMLSchema#string

Joerg Hartkamp

http://www.w3.org/2001/XMLSchema#string

Julian Sampson

http://www.w3.org/2001/XMLSchema#string

Masao Saitoh

http://www.w3.org/2001/XMLSchema#string

Richard Lamb

http://www.w3.org/2001/XMLSchema#string

Takahiro Nobukuni

http://www.w3.org/2001/XMLSchema#string

Wendy Roworth

http://www.w3.org/2001/XMLSchema#string

P2860

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

Phosphorylation and activation of p70s6k by PDK1

Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

Oncogenic kinase signalling

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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217–224

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10.1083/JCB.JCB.200206108

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2

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159

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11059872

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