Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
about
The haemopoietic stem cell: between apoptosis and self renewalCD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosisAML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocationApoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interactionTransgenic models of lymphoid neoplasia and development of a pan-hematopoietic vectorBCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineageInducible resistance to Fas-mediated apoptosis in B cells.Prospective isolation of human clonogenic common myeloid progenitors.Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?Disrupting the CD47-SIRPĪ± anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S.Disruption of differentiation in human cancer: AML shows the way.Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools.The Bcl-2 family: roles in cell survival and oncogenesis.Molecular therapeutic approaches to acute myeloid leukemia: targeting aberrant chromatin dynamics and signal transduction.Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cellsProapoptotic BID is required for myeloid homeostasis and tumor suppression.Animal models of acute myelogenous leukaemia - development, application and future perspectives.Lipopolysaccharides-Induced Suppression of Innate-Like B Cell Apoptosis Is Enhanced by CpG Oligodeoxynucleotide and Requires Toll-Like Receptors 2 and 4Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes.The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential.miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: results from a pilot, randomized, and controlled trialActivation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival.Review: genetic models of acute myeloid leukaemia.FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report.FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation.A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cells.Regulation of self-renewal in normal and cancer stem cells.Evolution of normal and neoplastic tissue stem cells: progress after Robert Hooke.Tumor-Initiating Cells: Emerging Biophysical Methods of Isolation.Human NK cells activated by EBV(+) lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells.AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia.Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation.G1-Cdk activity is required for both proliferation and viability of cytokine-dependent myeloid and erythroid cells.Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.
P2860
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P2860
Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
description
1998 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« Õ
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@hyw
1998 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ°ÕøÖÕ¬Õ«Õ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
artĆculu cientĆficu espublizĆ”u en 1998
@ast
im Juli 1998 verƶffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedeckĆ½ ÄlĆ”nok (publikovanĆ½ 1998/07/01)
@sk
vÄdeckĆ½ ÄlĆ”nek publikovanĆ½ v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/07/01)
@nl
Š½Š°ŃŠŗŠ¾Š²Š° ŃŃŠ°ŃŃŃ, Š¾ŠæŃŠ±Š»ŃŠŗŠ¾Š²Š°Š½Š° Š² Š»ŠøŠæŠ½Ń 1998
@uk
Ł
ŁŲ§ŁŲ© Ų¹ŁŁ
ŁŲ© (ŁŲ“Ų±ŲŖ ŁŁ ŁŁŁŁŁ 1998)
@ar
name
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@ast
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@en
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@nl
type
label
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@ast
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@en
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@nl
prefLabel
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@ast
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@en
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@nl
P2093
P921
P3181
P1433
P1476
Mice defective in two apoptosi ...... op acute myeloblastic leukemia
@en
P2093
E. Lagasse
I. L. Weissman
P304
P3181
P356
10.1016/S1074-7613(00)80587-7
P407
P577
1998-07-01T00:00:00Z