Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. - Wikidata - awgldk - TriplyDB

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

http://www.wikidata.org/entity/Q35811198

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CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.Glioblastoma cancer stem cells: Biomarker and therapeutic advances Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis Chronic myeloid leukemia: mechanisms of blastic transformation Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.Right on target: eradicating leukemic stem cells.Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells Cell Regulation of Proliferation and Differentiation ex vivo for Cells Containing Ph Chromosome in Chronic Myeloid Leukemia Diverging fates of cells of origin in acute and chronic leukaemia.Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.Normal and leukaemic stem cells.Cancer stem cells: lessons from leukaemia.Target for cancer therapy: proliferating cells or stem cells.Neutrophil-selective CD18 silencing using RNA interference in vivo Putative cancer stem cells in cutaneous malignancies.The cancer stem cell paradigm: a new understanding of tumor development and treatment.An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1.Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia.Hematopoietic developmental pathways: on cellular basis.Aberrant cytokine signaling in leukemia.BCR-ABL-transformed GMP as myeloid leukemic stem cells.Re-evaluating the role of BCR/ABL in chronic myelogenous leukemia Cancer stem cells in breast: current opinion and future challenges.Targeting the leukemic stem cell: the Holy Grail of leukemia therapy Molecular biology of bcr-abl1-positive chronic myeloid leukemia.Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target.Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder.FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation.A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cells.NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8.A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.Cancer stem cells and cancer therapy.

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P2860

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

http://www.wikidata.org/entity/Q35811198

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

@ast

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

@en

type

label

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

@ast

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

@en

prefLabel

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

@ast

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

@en

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PNAS.1633833100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

@en

P2093

David Traver

http://www.w3.org/2001/XMLSchema#string

Eric Lagasse

http://www.w3.org/2001/XMLSchema#string

Irving L Weissman

http://www.w3.org/2001/XMLSchema#string

Koichi Akashi

http://www.w3.org/2001/XMLSchema#string

Siddhartha Jaiswal

http://www.w3.org/2001/XMLSchema#string

Toshihiro Miyamoto

http://www.w3.org/2001/XMLSchema#string

P2860

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

Stem cells, cancer, and cancer stem cells

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

Light microscopic detection of BCR-ABL transcripts after in-cell RT-PCR: fusion gene expression might correlate with clinical evolution of chronic myeloid leukemia.

Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.

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10.1073/PNAS.1633833100

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100

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10635772

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12890867

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187741

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