C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
about
Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cellsImpaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signalingVRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancerMARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signalingComprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein networkNew role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylasesDifferential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signalingCell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cellsInflammatory bowel disease reveals the kinase activity of KSR1Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomesFunctional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.Complexity in KSR function revealed by Raf inhibitor and KSR structure studiesKSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motilityp14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasisOrganization of the ENaC-regulatory machineryConformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domainRaf-interactome in tuning the complexity and diversity of Raf function.Negative feedback regulation of the ERK1/2 MAPK pathwayRSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activationA CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membraneScaffolds are 'active' regulators of signaling modulesKSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signalsAKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascadeInsulin enhances growth hormone induction of the MEK/ERK signaling pathwayThe mouse kinome: discovery and comparative genomics of all mouse protein kinasesCoordinating ERK/MAPK signalling through scaffolds and inhibitorsGIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesionsMaintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylationLocalization of ERK/MAP kinase is regulated by the alphaherpesvirus tegument protein Us2First siRNA library screening in hard-to-transfect HUVEC cells.A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells.Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3.Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformationModulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphataseRegulation of glucose homeostasis by KSR1 and MARK2.Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.
P2860
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P2860
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
description
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im November 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/11/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/11/01)
@nl
наукова стаття, опублікована в листопаді 2001
@uk
مقالة علمية (نشرت في نوفمبر 2001)
@ar
name
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@ast
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@en
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@nl
type
label
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@ast
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@en
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@nl
prefLabel
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@ast
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@en
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@nl
P2093
P3181
P1433
P1476
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
@en
P2093
D K Morrison
H Piwnica-Worms
T Copeland
P304
P3181
P356
10.1016/S1097-2765(01)00383-5
P50
P577
2001-11-01T00:00:00Z