Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta
about
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switchSpecific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complexSequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta314-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapseADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling.Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activityThe organizing principle of the platelet glycoprotein Ib-IX-V complex.c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1balphaDynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo.The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activationA functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complexSrc family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit.Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα--14-3-3ζ] association.A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications.Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner.GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
P2860
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P2860
Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@ast
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@en
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@nl
type
label
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@ast
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@en
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@nl
prefLabel
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@ast
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@en
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@nl
P2093
P3181
P1433
P1476
Phosphoinositide 3-kinase form ...... Ib-IX-V complex and 14-3-3zeta
@en
P2093
P304
P3181
P407
P577
2000-07-01T00:00:00Z