Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
about
Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRPGTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expressionHuman GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzymeA yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactionsTetrahydrobiopterin biosynthesis, regeneration and functionsDeficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytesRecoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recyclingThe neurobiology of tetrahydrobiopterin biosynthesis: a model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neuronsCrystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterinLigand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexesPet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin NeuronsStructural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory proteinDecameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTPThe mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory proteinBiochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase ITetrahydrobiopterin in cardiovascular health and disease.A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin.Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein.Coordinate regulation of tetrahydrobiopterin turnover and phenylalanine hydroxylase activity in rat liver cellsThe N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP.Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production.Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.GCH1, BH4 and painEndothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing.Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approachesComplexity of dopamine metabolism.Correction of murine PKU following AAV-mediated intramuscular expression of a complete phenylalanine hydroxylating systemCharacterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responsesBiosynthesis of drosopterins, the red eye pigments of Drosophila melanogaster.GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein.Mechanisms of Inflammation-Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms.Interaction of human GTP cyclohydrolase I with its splice variants.GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide.GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.Structure and function of the aromatic amino acid hydroxylases.GTP cyclohydrolase I: purification, characterization, and effects of inhibition on nitric oxide synthase in nocardia species.Enzymic characterization of Bacillus subtilis GTP cyclohydrolase I. Evidence for a chemical dephosphorylation of dihydroneopterin triphosphateDirect binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesisAnti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase.
P2860
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P2860
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
description
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1993
@ast
im Juni 1993 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1993/06/04)
@sk
vědecký článek publikovaný v roce 1993
@cs
wetenschappelijk artikel (gepubliceerd op 1993/06/04)
@nl
наукова стаття, опублікована в червні 1993
@uk
name
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@ast
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@en
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@nl
type
label
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@ast
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@en
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@nl
prefLabel
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@ast
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@en
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@nl
P2093
P356
P1433
P1476
Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
@en
P2093
H. Kagamiyama
K. Hatakeyama
P304
P356
10.1126/SCIENCE.8502995
P407
P577
1993-06-04T00:00:00Z