GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression
about
GTP cyclohydrolase I utilizes metal-free GTP as its substrateTetrahydrobiopterin biosynthesis, regeneration and functionsNitric oxide synthases in heart failureCrystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexesStructural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory proteinDecameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTPThe mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory proteinCoherent conformational degrees of freedom as a structural basis for allosteric communication.Tetrahydrobiopterin in cardiovascular health and disease.Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production.GCH1, BH4 and painCharacterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responsesSynthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein.Nitric oxide formation in acutely rejecting cardiac allografts correlates with GTP cyclohydrolase I activity.Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones.Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization.Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C.GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis.Structures and reaction mechanisms of GTP cyclohydrolases.
P2860
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P2860
GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@ast
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@en
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@en-gb
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@nl
type
label
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@ast
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@en
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@en-gb
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@nl
prefLabel
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@ast
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@en
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@en-gb
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@nl
P2093
P2860
P356
P1476
GTP cyclohydrolase I feedback ...... ning, and bacterial expression
@en
P2093
J M Brewer
K Hatakeyama
T Yoneyama
P2860
P304
P356
10.1074/JBC.272.15.9690
P407
P577
1997-04-11T00:00:00Z