Enzymes and reactions at the eukaryotic DNA replication fork
about
Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceThe RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesWerner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activityArginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determinationWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkThe DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activityStimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iotaPhysical and functional interactions of human DNA polymerase eta with PCNAThe 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityComponents of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processingAn alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicaseOkazaki fragment maturation: nucleases take centre stageAn interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joiningModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesContributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complexMechanisms of accurate translesion synthesis by human DNA polymerase etaEnzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2In vivo and in vitro studies of Mgs1 suggest a link between genome instability and Okazaki fragment processing.Advances in mechanisms of genetic instability related to hereditary neurological diseases.Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-AnalysisMolecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshiiCellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active siteSaccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nucleaseThe absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair.The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.Interactions among DNA ligase I, the flap endonuclease and proliferating cell nuclear antigen in the expansion and contraction of CAG repeat tracts in yeastDna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation.Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigenPhosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulationFlap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason scoreDNA polymerase II (epsilon) of Saccharomyces cerevisiae dissociates from the DNA template by sensing single-stranded DNAUnlocking the sugar "steric gate" of DNA polymerasesFission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repairIdentification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in methodProliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stageMolecular architecture of the mouse DNA polymerase alpha-primase complex
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P2860
Enzymes and reactions at the eukaryotic DNA replication fork
description
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Februar 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/02/21)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/02/21)
@nl
наукова стаття, опублікована в лютому 1997
@uk
name
Enzymes and reactions at the eukaryotic DNA replication fork
@ast
Enzymes and reactions at the eukaryotic DNA replication fork
@en
Enzymes and reactions at the eukaryotic DNA replication fork
@nl
type
label
Enzymes and reactions at the eukaryotic DNA replication fork
@ast
Enzymes and reactions at the eukaryotic DNA replication fork
@en
Enzymes and reactions at the eukaryotic DNA replication fork
@nl
prefLabel
Enzymes and reactions at the eukaryotic DNA replication fork
@ast
Enzymes and reactions at the eukaryotic DNA replication fork
@en
Enzymes and reactions at the eukaryotic DNA replication fork
@nl
P2093
P2860
P356
P1476
Enzymes and reactions at the eukaryotic DNA replication fork
@en
P2093
L. A. Henricksen
R. A. Bambara
R. S. Murante
P2860
P304
P356
10.1074/JBC.272.8.4647
P407
P577
1997-02-21T00:00:00Z