Vav2 is an activator of Cdc42, Rac1, and RhoA - Wikidata - awgldk - TriplyDB

Vav2 is an activator of Cdc42, Rac1, and RhoA

Vav2 is an activator of Cdc42, Rac1, and RhoA

http://www.wikidata.org/entity/Q28610652

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Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms RhoG signals in parallel with Rac1 and Cdc42 Crucial structural role for the PH and C1 domains of the Vav1 exchange factor The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins Vav family proteins couple to diverse cell surface receptors TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway Vav2 is required for cell spreading Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response A glimpse of the ERM proteins Phosphorylation-mediated regulation of GEFs for RhoA Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton Vav family exchange factors: an integrated regulatory and functional view PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP.Functional characterization and cellular dynamics of the CDC-42 - RAC - CDC-24 module in Neurospora crassa Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1 LOVTRAP: an optogenetic system for photoinduced protein dissociation Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer.RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development.Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation Engineering extrinsic disorder to control protein activity in living cells.p120 catenin regulates the actin cytoskeleton via Rho family GTPases.RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry.Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.

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Vav2 is an activator of Cdc42, Rac1, and RhoA

http://www.wikidata.org/entity/Q28610652

description

2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

artículu científicu espublizáu en 2000

@ast

im April 2000 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2000/04/07)

@sk

vědecký článek publikovaný v roce 2000

@cs

wetenschappelijk artikel (gepubliceerd op 2000/04/07)

@nl

наукова стаття, опублікована у квітні 2000

@uk

name

Vav2 is an activator of Cdc42, Rac1, and RhoA

@ast

Vav2 is an activator of Cdc42, Rac1, and RhoA

@en

Vav2 is an activator of Cdc42, Rac1, and RhoA

@nl

type

label

Vav2 is an activator of Cdc42, Rac1, and RhoA

@ast

Vav2 is an activator of Cdc42, Rac1, and RhoA

@en

Vav2 is an activator of Cdc42, Rac1, and RhoA

@nl

prefLabel

Vav2 is an activator of Cdc42, Rac1, and RhoA

@ast

Vav2 is an activator of Cdc42, Rac1, and RhoA

@en

Vav2 is an activator of Cdc42, Rac1, and RhoA

@nl

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JBC.275.14.10141

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Journal of Biological Chemistry

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Vav2 is an activator of Cdc42, Rac1, and RhoA

@en

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B. Liu

http://www.w3.org/2001/XMLSchema#string

C. J. Der

http://www.w3.org/2001/XMLSchema#string

D. Chiang

http://www.w3.org/2001/XMLSchema#string

K. Abe

http://www.w3.org/2001/XMLSchema#string

K. Burridge

http://www.w3.org/2001/XMLSchema#string

K. D. Ritola

http://www.w3.org/2001/XMLSchema#string

K. L. Rossman

http://www.w3.org/2001/XMLSchema#string

S. L. Campbell

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1

CDC42 and FGD1 cause distinct signaling and transforming activities.

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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10141–10149

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scholarly article

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3401604

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P356

10.1074/JBC.275.14.10141

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14

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P478

275

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P577

2000-04-07T00:00:00Z

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P5875

12571033

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P698

10744696

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