Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activationRequirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytesASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.Control of glycogen synthesis in cultured human muscle cellsFyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseThe isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphataseRegulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligandsIdentification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxisAkt is negatively regulated by the MULAN E3 ligaseKinetic mechanism of AKT/PKB enzyme familyShepherding AKT and androgen receptor by Ack1 tyrosine kinaseClipR-59 interacts with Akt and regulates Akt cellular compartmentalizationEtk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cellsInhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alphaEndosomal localization and function of sorting nexin 1Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2The PI3K-PDK1 connection: more than just a road to PKBSerum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathwayA phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanismRegulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesisOverexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activityIdentification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKAA PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansThe mTOR signalling pathway in human cancerExtreme-longevity mutations orchestrate silencing of multiple signaling pathwaysRegulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytesModulation of Akt kinase activity by binding to Hsp90Protein kinase B phosphorylates AHNAK and regulates its subcellular localizationAn amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machineryPI3K and AKT: Unfaithful Partners in CancerFOXO transcription factors throughout T cell biologyPerspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organismsAutophagy is essential to support skeletal muscle plasticity in response to endurance exerciseSystemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injuryIntegrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane
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P2860
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
description
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1997
@ast
im Juli 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/07/25)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/07/25)
@nl
наукова стаття, опублікована в липні 1997
@uk
name
Dual role of phosphatidylinosi ...... activation of protein kinase B
@ast
Dual role of phosphatidylinosi ...... activation of protein kinase B
@en
Dual role of phosphatidylinosi ...... activation of protein kinase B
@nl
type
label
Dual role of phosphatidylinosi ...... activation of protein kinase B
@ast
Dual role of phosphatidylinosi ...... activation of protein kinase B
@en
Dual role of phosphatidylinosi ...... activation of protein kinase B
@nl
prefLabel
Dual role of phosphatidylinosi ...... activation of protein kinase B
@ast
Dual role of phosphatidylinosi ...... activation of protein kinase B
@en
Dual role of phosphatidylinosi ...... activation of protein kinase B
@nl
P2093
P3181
P1433
P1476
Dual role of phosphatidylinosi ...... activation of protein kinase B
@en
P2093
A. B. Holmes
C. B. Reese
F. McCormick
G. F. Painter
L. R. Stephens
P. R. Gaffney
P. T. Hawkins
T. Copeland
P304
P3181
P356
10.1126/SCIENCE.277.5325.567
P407
P577
1997-07-25T00:00:00Z