Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase
about
Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytesRequirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) geneHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeTYK2 kinase activity is required for functional type I interferon responses in vivoInterferon induction and function at the mucosal surface.An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities.STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptorDysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain.miR-744 enhances type I interferon signaling pathway by targeting PTP1B in primary human renal mesangial cellsIn vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activityAssessment of bone dysplasia by micro-CT and glycosaminoglycan levels in mouse models for mucopolysaccharidosis type I, IIIA, IVA, and VIIMechanism of shortened bones in mucopolysaccharidosis VIIThe oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells.Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses.STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling.STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cellsInterferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt.A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion.Interferon-α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh-7 cells transfected with hepatitis B virus X gene-expressing lentivirus.Phosphorylation of STAT2A novel MEK2/PI3Kδ pathway controls the expression of IL-1 receptor antagonist in IFN-β-activated human monocytes.
P2860
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P2860
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase
description
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im November 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/11/05)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/11/05)
@nl
наукова стаття, опублікована в листопаді 1999
@uk
name
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@ast
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@en
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@nl
type
label
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@ast
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@en
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@nl
prefLabel
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@ast
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@en
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@nl
P2093
P2860
P3181
P356
P1476
Catalytically active TYK2 is e ...... on of phosphoinositol 3-kinase
@en
P2093
A. Wolfman
D. W. Leaman
E. N. Fish
M. R. Rani
R. M. Ransohoff
P2860
P304
32507–32511
P3181
P356
10.1074/JBC.274.45.32507
P407
P577
1999-11-05T00:00:00Z