TYK2 kinase activity is required for functional type I interferon responses in vivo
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Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivoHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeAn image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mousePotential viral pathogenic mechanism in human type 1 diabetesSTAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activityInhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.Therapeutic potential of tyrosine kinase 2 in autoimmunity.Toward selective TYK2 inhibitors as therapeutic agents for the treatment of inflammatory diseases.Selective JAK inhibitors.Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases.SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells.Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses.Regulating STING in health and diseaseDifferential expression of innate immune response genes in clinical phases of chronic hepatitis B infection.A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease.Stat5 gene dosage in T cells modulates CD8+T-cell homeostasis and attenuates contact hypersensitivity response in mice
P2860
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P2860
TYK2 kinase activity is required for functional type I interferon responses in vivo
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
TYK2 kinase activity is required for functional type I interferon responses in vivo
@ast
TYK2 kinase activity is required for functional type I interferon responses in vivo
@en
TYK2 kinase activity is required for functional type I interferon responses in vivo
@nl
type
label
TYK2 kinase activity is required for functional type I interferon responses in vivo
@ast
TYK2 kinase activity is required for functional type I interferon responses in vivo
@en
TYK2 kinase activity is required for functional type I interferon responses in vivo
@nl
prefLabel
TYK2 kinase activity is required for functional type I interferon responses in vivo
@ast
TYK2 kinase activity is required for functional type I interferon responses in vivo
@en
TYK2 kinase activity is required for functional type I interferon responses in vivo
@nl
P2093
P2860
P50
P3181
P1433
P1476
TYK2 kinase activity is required for functional type I interferon responses in vivo
@en
P2093
Barbara Wallner
Caroline Lassnig
Christian Gausterer
Christian Semper
Ingeborg Teppner-Klymiuk
Julianna Kobolak
Marina Karaghiosoff
Michaela Prchal-Murphy
Nicole R Leitner
Simone Müller
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0039141
P407
P577
2012-01-01T00:00:00Z