CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization.
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Structural mechanism of trimeric HIV-1 envelope glycoprotein activationDynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane FusionStructure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding siteAntigenic properties of the human immunodeficiency virus envelope glycoprotein gp120 on virions bound to target cellsThe human immunodeficiency virus type 1 gp120 V2 domain mediates gp41-independent intersubunit contacts.Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesDiverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 bindingFine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display librariesUse of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120.Solution structure, conformational dynamics, and CD4-induced activation in full-length, glycosylated, monomeric HIV gp120Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes.Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.NMR structural analysis of a peptide mimic of the bridging sheet of HIV-1 gp120 in methanol and water.An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10sCD4-17b bifunctional protein: extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates.Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation.Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cellsEvaluation of CD4-CD4i antibody architectures yields potent, broadly cross-reactive anti-human immunodeficiency virus reagents.Influence of novel CD4 binding-defective HIV-1 envelope glycoprotein immunogens on neutralizing antibody and T-cell responses in nonhuman primatesVariants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycanCharacterization of gp120 and its single-chain derivatives, gp120-CD4D12 and gp120-M9: implications for targeting the CD4i epitope in human immunodeficiency virus vaccine design.Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophagesA V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer.CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodiesCharacterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeysDifferences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry.Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains.Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolateSequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120.Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domainsSelective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120Enhanced binding of antibodies to neutralization epitopes following thermal and chemical inactivation of human immunodeficiency virus type 1.Characterization of a macaque recombinant monoclonal antibody that binds to a CD4-induced epitope and neutralizes simian immunodeficiency virusHeterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant.Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individualsImproved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers.Induction of neutralizing antibodies and gag-specific cellular immune responses to an R5 primary isolate of human immunodeficiency virus type 1 in rhesus macaques.Antigenic properties of the human immunodeficiency virus envelope during cell-cell fusionIncreased neutralization sensitivity of CD4-independent human immunodeficiency virus variants
P2860
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P2860
CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
CD4-Induced conformational cha ...... virus entry and neutralization
@nl
CD4-Induced conformational cha ...... irus entry and neutralization.
@ast
CD4-Induced conformational cha ...... irus entry and neutralization.
@en
type
label
CD4-Induced conformational cha ...... virus entry and neutralization
@nl
CD4-Induced conformational cha ...... irus entry and neutralization.
@ast
CD4-Induced conformational cha ...... irus entry and neutralization.
@en
prefLabel
CD4-Induced conformational cha ...... virus entry and neutralization
@nl
CD4-Induced conformational cha ...... irus entry and neutralization.
@ast
CD4-Induced conformational cha ...... irus entry and neutralization.
@en
P2093
P2860
P1433
P1476
CD4-Induced conformational cha ...... irus entry and neutralization.
@en
P2093
G Denisova
J Gershoni
J Robinson
N Sullivan
Q Sattentau
P2860
P304
P577
1998-06-01T00:00:00Z