about
HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificityThe good and the bad faces of STAT1 in solid tumoursInducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivoConditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infectionCDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon responseStructural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidaseA completely foreign receptor can mediate an interferon-gamma-like response.Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesisTYK2 kinase activity is required for functional type I interferon responses in vivoTyk2 and Stat3 regulate brown adipose tissue differentiation and obesityA time- and dose-dependent STAT1 expression system.The impact of tyrosine kinase 2 (Tyk2) on the proteome of murine macrophages and their response to lipopolysaccharide (LPS).Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes.Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses.STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27Host-cell sensors for Plasmodium activate innate immunity against liver-stage infectionMutational switch of an IL-6 response to an interferon-gamma-like response.Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription.Of JAKs, STATs, blind watchmakers, jeeps and trains.Reversible inhibition of murine cytomegalovirus replication by gamma interferon (IFN-γ) in primary macrophages involves a primed type I IFN-signaling subnetwork for full establishment of an immediate-early antiviral state.Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in miceIn vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activityIntestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.Studying human pathogens in animal models: fine tuning the humanized mouse.Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis.Intestinal Microbiota Signatures Associated with Inflammation History in Mice Experiencing Recurring Colitis.cDNA cloning and expression of secreted Xenopus laevis dipeptidyl aminopeptidase IV.Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes.Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity.Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery.Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity.Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays.Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice.Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillanceImportant scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Birgit Strobl
@ast
Birgit Strobl
@en
Birgit Strobl
@es
Birgit Strobl
@nl
Birgit Strobl
@sl
type
label
Birgit Strobl
@ast
Birgit Strobl
@en
Birgit Strobl
@es
Birgit Strobl
@nl
Birgit Strobl
@sl
prefLabel
Birgit Strobl
@ast
Birgit Strobl
@en
Birgit Strobl
@es
Birgit Strobl
@nl
Birgit Strobl
@sl
P106
P21
P31
P496
0000-0001-5716-3212