The kinase domains of obscurin interact with intercellular adhesion proteins
about
Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-lineGiant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunitThe SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurinObscure functions: the location-function relationship of obscurins.Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cellsObscurins: Goliaths and Davids take over non-muscle tissues.Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.The Phosphorylation Profile of Myosin Binding Protein-C Slow is Dynamically Regulated in Slow-Twitch Muscles in Health and Disease.Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.Obscurins: unassuming giants enter the spotlight.Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.The sarcomeric M-region: a molecular command center for diverse cellular processes.Myofilaments: Movers and Rulers of the Sarcomere.Obscurin variants and inherited cardiomyopathies.Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle.Twitchin kinase inhibits muscle activity.Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.The potential of obscurin as a therapeutic target in muscle disorders.
P2860
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P2860
The kinase domains of obscurin interact with intercellular adhesion proteins
description
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2013 թվականի մայիսին հրատարակված գիտական հոդված
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artículu científicu espublizáu en 2013
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scientific journal article
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wetenschappelijk artikel (gepubliceerd op 2013/05/01)
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wissenschaftlicher Artikel
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наукова стаття, опублікована в травні 2013
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مقالة علمية (نشرت في مايو 2013)
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name
The kinase domains of obscurin interact with intercellular adhesion proteins
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The kinase domains of obscurin interact with intercellular adhesion proteins
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type
label
The kinase domains of obscurin interact with intercellular adhesion proteins
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The kinase domains of obscurin interact with intercellular adhesion proteins
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prefLabel
The kinase domains of obscurin interact with intercellular adhesion proteins
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The kinase domains of obscurin interact with intercellular adhesion proteins
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P2860
P921
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P356
P1433
P1476
The kinase domains of obscurin interact with intercellular adhesion proteins
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P2093
Aikaterini Kontrogianni-Konstantopoulos
Li-Yen R. Hu
P2860
P304
P3181
P356
10.1096/FJ.12-221317
P407
P577
2013-05-01T00:00:00Z