Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance

Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance

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http://www.wikidata.org/entity/Q33713315
The kinase domains of obscurin interact with intercellular adhesion proteinsGiant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunitLoss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cellsGenetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.Obscurins: Goliaths and Davids take over non-muscle tissues.Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.Titin and obscurin: giants holding hands and discovery of a new Ig domain subsetObscurins: unassuming giants enter the spotlight.The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia.Characterization of potential driver mutations involved in human breast cancer by computational approaches.Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis.The potential of obscurin as a therapeutic target in muscle disorders.
P2860

Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance

Item
http://www.wikidata.org/entity/Q33713315
description
2012 nî lūn-bûn
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2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Loss of giant obscurins promot ...... l through apoptotic resistance
@ast
Loss of giant obscurins promot ...... l through apoptotic resistance
@en
type
label
Loss of giant obscurins promot ...... l through apoptotic resistance
@ast
Loss of giant obscurins promot ...... l through apoptotic resistance
@en
prefLabel
Loss of giant obscurins promot ...... l through apoptotic resistance
@ast
Loss of giant obscurins promot ...... l through apoptotic resistance
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932
P356
P1433
P1476
Loss of giant obscurins promot ...... l through apoptotic resistance
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932