FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
about
In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingCalmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channelsNovel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.FRET-based trilateration of probes bound within functional ryanodine receptors.Site-specific labeling of the type 1 ryanodine receptor using biarsenical fluorophores targeted to engineered tetracysteine motifsEssential Role of Calmodulin in RyR Inhibition by Dantrolene.Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.Calmodulin-binding locations on the skeletal and cardiac ryanodine receptorsN-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteinsS100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signalingDivergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.EL20, A Potent Antiarrhythmic Compound, Selectively Inhibits Calmodulin Deficient Ryanodine Receptor Type 2.Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.
P2860
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P2860
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
description
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
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im November 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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wetenschappelijk artikel (gepubliceerd op 2011/11/02)
@nl
наукова стаття, опублікована в листопаді 2011
@uk
مقالة علمية (نشرت في 2-11-2011)
@ar
name
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
@ast
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
@en
type
label
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
@ast
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
@en
prefLabel
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
@ast
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
@en
P2093
P2860
P921
P1433
P1476
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel
@en
P2093
Bradley R Fruen
Florentin R Nitu
Trinh D Nguyen
P2860
P304
P356
10.1016/J.BPJ.2011.09.030
P407
P577
2011-11-01T00:00:00Z