Extended longevity in mice lacking the insulin receptor in adipose tissue
about
Evolutionary origins of insulin resistance: a behavioral switch hypothesisInsulin in central nervous system: more than just a peripheral hormoneSirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gammaEvidence that the gene encoding insulin degrading enzyme influences human lifespanEvolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in miceExtension of chronological life span in yeast by decreased TOR pathway signalingThe TOR pathway comes of ageRapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevityEvaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous miceEndocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouseTelomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerChemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processesGrowth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humansSingle-gene mutations and healthy ageing in mammalsExtreme-longevity mutations orchestrate silencing of multiple signaling pathwaysKv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null miceRegulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayRole of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models.FOXO3A genotype is strongly associated with human longevitySuppression of aging in mice by the hormone KlothoSIRT6 in DNA repair, metabolism and ageingAdipose is a conserved dosage-sensitive antiobesity geneRole of visceral adipose tissue in agingKlotho and agingThe conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life spanBiological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormonesSHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegansIntermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intakeTwo faces of p53: aging and tumor suppressionSirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cellsRegulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genesRole of leptin resistance in the development of obesity in older patientsMetabolic homeostasis as the cornerstone of agingCaenorhabditis elegans as a model organism to study APP functionFOXO3: A Major Gene for Human Longevity--A Mini-ReviewModulation of the transcriptional activity of peroxisome proliferator-activated receptor gamma by protein-protein interactions and post-translational modificationsdbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental ArrestThe DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylationInterplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogasterInsulin signaling and dietary restriction differentially influence the decline of learning and memory with age
P2860
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P2860
Extended longevity in mice lacking the insulin receptor in adipose tissue
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Extended longevity in mice lacking the insulin receptor in adipose tissue
@ast
Extended longevity in mice lacking the insulin receptor in adipose tissue
@en
type
label
Extended longevity in mice lacking the insulin receptor in adipose tissue
@ast
Extended longevity in mice lacking the insulin receptor in adipose tissue
@en
prefLabel
Extended longevity in mice lacking the insulin receptor in adipose tissue
@ast
Extended longevity in mice lacking the insulin receptor in adipose tissue
@en
P3181
P356
P1433
P1476
Extended longevity in mice lacking the insulin receptor in adipose tissue
@en
P2093
P3181
P356
10.1126/SCIENCE.1078223
P407
P577
2003-01-24T00:00:00Z