Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice - Wikidata - awgldk - TriplyDB

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

http://www.wikidata.org/entity/Q24535960

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Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity Aging as an event of proteostasis collapse Coenzyme Q and Its Role in the Dietary Therapy against Aging Mitohormesis Axis of ageing: telomeres, p53 and mitochondria A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging The cell biology of aging Genetics of aging in Caenorhabditis elegans Evolutionary pressure on mitochondrial cytochrome b is consistent with a role of CytbI7T affecting longevity during caloric restriction Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice Early mitochondrial dysfunction in long-lived Mclk1+/- mice Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms ROS function in redox signaling and oxidative stress The cell-non-autonomous nature of electron transport chain-mediated longevity Physiological roles of mitochondrial reactive oxygen species Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease.Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans.Aging: Dial M for Mitochondria Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1(+/)(-) mutants Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan.The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.An overview of current mouse models recapitulating coenzyme q10 deficiency syndrome When a theory of aging ages badly.Taking a "good" look at free radicals in the aging process.A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes.Signaling the mitochondrial unfolded protein response.The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins Mitochondrial-nuclear epistasis: implications for human aging and longevity.Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.The paradox of mitochondrial dysfunction and extended longevity.An enhanced immune response of Mclk1⁺/⁻ mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging.Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis.Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.

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Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

http://www.wikidata.org/entity/Q24535960

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2005 nî lūn-bûn

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2005年の論文

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Evolutionary conservation of t ...... r fitness and lifespan in mice

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Eric Shoubridge

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Eve Bigras

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Ning Jiang

http://www.w3.org/2001/XMLSchema#string

Siegfried Hekimi

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Xingxing Liu

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P2860

A C. elegans mutant that lives twice as long as wild type

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Aging and genome maintenance: lessons from the mouse?

Antioncogenes and human cancer.

The comet assay for DNA damage and repair: principles, applications, and limitations

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury

Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis

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10.1101/GAD.1352905

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16195414

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1257397

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