about
Digitoxin and its analogs as novel cancer therapeuticsMicroRNAs in the DNA Damage/Repair Network and CancerDigitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cellsCHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancerTrans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeImpaired DNA damage checkpoint response in MIF-deficient micePhosphorylation of HuR by Chk2 regulates SIRT1 expressionDNA-damage-responsive acetylation of pRb regulates binding to E2F-1TAO kinases mediate activation of p38 in response to DNA damageChk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restartDNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilizationThe CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsRegulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.The DNA damage pathway regulates innate immune system ligands of the NKG2D receptorChk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repairTumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activationInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingChk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genesNek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylationThe cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damagePPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsAlternative cyclin D1 splice forms differentially regulate the DNA damage responseDifferential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysisImplication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationIrofulven induces replication-dependent CHK2 activation related to p53 statusLoss of Geminin induces rereplication in the presence of functional p53Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestDNA and the chromosome - varied targets for chemotherapyTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyNicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A ReviewHuman Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical CancerThe DNA damage response induced by infection with human cytomegalovirus and other virusesChemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingDNA damage associated with mitosis and cytokinesis failureRoles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implicationsThe convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancerSpindle assembly checkpoint acquisition at the mid-blastula transitionStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Chk1 and Chk2 kinases in checkpoint control and cancer
@ast
Chk1 and Chk2 kinases in checkpoint control and cancer
@en
type
label
Chk1 and Chk2 kinases in checkpoint control and cancer
@ast
Chk1 and Chk2 kinases in checkpoint control and cancer
@en
prefLabel
Chk1 and Chk2 kinases in checkpoint control and cancer
@ast
Chk1 and Chk2 kinases in checkpoint control and cancer
@en
P3181
P1433
P1476
Chk1 and Chk2 kinases in checkpoint control and cancer
@en
P2093
P3181
P356
10.1016/S1535-6108(03)00110-7
P407
P577
2003-05-01T00:00:00Z