A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
about
An overview of Cdk1-controlled targets and processesCritical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpointPolo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyDisruption of mechanisms that prevent rereplication triggers a DNA damage responseActivation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firingChk1 and p21 cooperate to prevent apoptosis during DNA replication fork stressAn N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing.Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forksDamage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeastFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressDNA synthesis at individual replication forks requires the essential initiation factor Cdc45pHistone H3 lysine 56 acetylation and the response to DNA replication fork damageDNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1Loss of Geminin induces rereplication in the presence of functional p53Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replicationSurveying genome replication.The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesisSaccharomyces cerevisiae Dbf4 Has Unique Fold Necessary for Interaction with Rad53 KinaseXrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination.Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Mcm2 phosphorylation and the response to replicative stressActivation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2Esc4/Rtt107 and the control of recombination during replication.Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair.Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae.Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.Two mcm3 mutations affect different steps in the initiation of DNA replication.The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks.A role for H2B ubiquitylation in DNA replicationFunctions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress.Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae.A requirement for recombinational repair in Saccharomyces cerevisiae is caused by DNA replication defects of mec1 mutantsGenome-wide localization of Rrm3 and Pif1 DNA helicases at stalled active and inactive DNA replication forks of Saccharomyces cerevisiae.ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress.
P2860
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P2860
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
description
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1998
@ast
scientific article (publication date: 8 October 1998)
@en
wetenschappelijk artikel (gepubliceerd op 1998/10/08)
@nl
наукова стаття, опублікована в жовтні 1998
@uk
مقالة علمية (نشرت في 8-10-1998)
@ar
name
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
@ast
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
@en
type
label
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
@ast
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
@en
prefLabel
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
@ast
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
@en
P3181
P356
P1433
P1476
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
@en
P2093
Diffley JF
Santocanale C
P2888
P304
P3181
P356
10.1038/27001
P407
P577
1998-10-01T00:00:00Z
P5875
P6179
1009092225