The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon
about
An unappreciated role for RNA surveillanceCharacterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayInteraction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeastMammalian orthologues of a yeast regulator of nonsense transcript stabilityThe surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsA 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.The hDcp2 protein is a mammalian mRNA decapping enzymeIdentification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexesSMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeastPositional cloning of the combined hyperlipidemia gene Hyplip1Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3"Using the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteinsA GFP-based reporter system to monitor nonsense-mediated mRNA decayRibosome-based quality control of mRNA and nascent peptidesNonsense-mediated mRNA decay: novel mechanistic insights and biological impactMechanism and regulation of the nonsense-mediated decay pathwayProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsNonsense-mediated mRNA decay: inter-individual variability and human diseaseThe Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality ControlHelicase and capping enzyme active site mutations in brome mosaic virus protein 1a cause defects in template recruitment, negative-strand RNA synthesis, and viral RNA capping.Long-distance base pairing in flock house virus RNA1 regulates subgenomic RNA3 synthesis and RNA2 replication.Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock.Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover.Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeastSaccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay.NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae.Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle.A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3pPosttranscriptional control of gene expression in yeast.A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3pUpf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastEbs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae.Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.
P2860
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P2860
The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon
description
1991 nî lūn-bûn
@nan
1991 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
The product of the yeast UPF1 ...... ranslational termination codon
@ast
The product of the yeast UPF1 ...... ranslational termination codon
@en
type
label
The product of the yeast UPF1 ...... ranslational termination codon
@ast
The product of the yeast UPF1 ...... ranslational termination codon
@en
prefLabel
The product of the yeast UPF1 ...... ranslational termination codon
@ast
The product of the yeast UPF1 ...... ranslational termination codon
@en
P2093
P3181
P356
P1433
P1476
The product of the yeast UPF1 ...... ranslational termination codon
@en
P2093
P304
P3181
P356
10.1101/GAD.5.12A.2303
P407
P577
1991-12-01T00:00:00Z