Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.
about
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.The effect of eukaryotic release factor depletion on translation termination in human cell linesBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayInteraction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeastInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysUpf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayThe surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsA competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decayIdentification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexesSMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeastItt1p, a novel protein inhibiting translation termination in Saccharomyces cerevisiaeHepatitis C virus internal ribosome entry site-dependent translation in Saccharomyces cerevisiae is independent of polypyrimidine tract-binding protein, poly(rC)-binding protein 2, and La proteinAbsence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay.The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1Tpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae.The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae.Posttranscriptional control of gene expression in yeast.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3pUpf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastOverexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance.Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 proteinIdentification of the gene encoding scHelI, a DNA helicase from Saccharomyces cerevisiae.Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryEvidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathwayUpf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation.Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.Mutations in VPS16 and MRT1 stabilize mRNAs by activating an inhibitor of the decapping enzymeUpf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs.Is there a classical nonsense-mediated decay pathway in trypanosomes?Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors.Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation.
P2860
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P2860
Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.
description
1996 nî lūn-bûn
@nan
1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Identification and characteriz ...... complex but not mRNA turnover.
@ast
Identification and characteriz ...... complex but not mRNA turnover.
@en
Identification and characteriz ...... complex but not mRNA turnover.
@nl
type
label
Identification and characteriz ...... complex but not mRNA turnover.
@ast
Identification and characteriz ...... complex but not mRNA turnover.
@en
Identification and characteriz ...... complex but not mRNA turnover.
@nl
prefLabel
Identification and characteriz ...... complex but not mRNA turnover.
@ast
Identification and characteriz ...... complex but not mRNA turnover.
@en
Identification and characteriz ...... complex but not mRNA turnover.
@nl
P2093
P2860
P3181
P356
P1476
Identification and characteriz ...... complex but not mRNA turnover.
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.16.10.5491
P407
P577
1996-10-01T00:00:00Z