Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay.
about
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeastThe surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsIdentification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexesSMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeastUsing the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteinsTemperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover.Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes.Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeastThe shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae.Posttranscriptional control of gene expression in yeast.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3pYeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastTranscript selection and the recruitment of mRNA decay factors for NMD in Saccharomyces cerevisiaeEvidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathwayInactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.Nonsense-mediated mRNA decapping occurs on polyribosomes in Saccharomyces cerevisiaeTelomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway.Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome.Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs.Nonsense-mediated decay of human HEXA mRNA.Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiaeGene set coregulated by the Saccharomyces cerevisiae nonsense-mediated mRNA decay pathway.Overexpression of truncated Nmd3p inhibits protein synthesis in yeast.Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitutionSMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiaeThe role of Upf proteins in modulating the translation read-through of nonsense-containing transcriptsAccumulation of mRNA coding for the ctf13p kinetochore subunit of Saccharomyces cerevisiae depends on the same factors that promote rapid decay of nonsense mRNAs.Multiple transcripts from a 3'-UTR reporter vary in sensitivity to nonsense-mediated mRNA decay in Saccharomyces cerevisiaeThe Upf-dependent decay of wild-type PPR1 mRNA depends on its 5'-UTR and first 92 ORF nucleotidesNonsense-mediated mRNA decay: insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3, and Upf3X proteins.Initiation-mediated mRNA decay in yeast affects heat-shock mRNAs, and works through decapping and 5'-to-3' hydrolysis.A highly conserved region essential for NMD in the Upf2 N-terminal domainNMD: At the crossroads between translation termination and ribosome recycling.
P2860
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P2860
Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay.
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@ast
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@en
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@nl
type
label
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@ast
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@en
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@nl
altLabel
Relationship between yeast pol ...... quired for nonsense mRNA decay
@en
prefLabel
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@ast
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@en
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@nl
P2093
P2860
P356
P1476
Relationship between yeast pol ...... uired for nonsense mRNA decay.
@en
P2093
J N Dahlseid
L R Schenkman
M J Lelivelt
M R Culbertson
P2860
P304
P356
10.1074/JBC.272.35.22163
P407
P577
1997-08-29T00:00:00Z