Regulation of dendritic spine morphology and synaptic function by Shank and Homer
about
The Homer family proteinsHaploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communicationReduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesA circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbĪ±The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.Distinctive phenotype in 9 patients with deletion of chromosome 1q24-q25Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disordersControl of sleep and wakefulnessMultiple rare variants in the etiology of autism spectrum disordersThe postsynaptic density proteins Homer and Shank form a polymeric network structureIdentification of a recurrent breakpoint within the SHANK3 gene in the 22q13.3 deletion syndromeThe neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cellsMolecular characterisation of the 22q13 deletion syndrome supports the role of haploinsufficiency of SHANK3/PROSAP2 in the major neurological symptomsAbelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formationCellular and synaptic network defects in autismTherapeutic approaches for shankopathiesEnlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Rapid redistribution of synaptic PSD-95 in the neocortex in vivoProteins that promote filopodia stability, but not number, lead to more axonal-dendritic contactsDiscovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domainGenetic aspects of autism spectrum disorders: insights from animal modelsActin-Dependent Alterations of Dendritic Spine Morphology in ShankopathiesA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisMice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.22q13.3 deletion syndrome: clinical and molecular analysis using array CGHDeveloping and applying the adverse outcome pathway concept for understanding and predicting neurotoxicityMultiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampusEssential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulationNeuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storageApolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptorSmaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron culturesCocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signalingSAP97 directs the localization of Kv4.2 to spines in hippocampal neurons: regulation by CaMKIIPSD-95 is required to sustain the molecular organization of the postsynaptic density
P2860
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P2860
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
description
2001 nĆ® lÅ«n-bĆ»n
@nan
2001 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« Õ
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@hyw
2001 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ°ÕøÖÕ¬Õ«Õ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
2001幓ć®č«ę
@ja
2001幓č«ę
@yue
2001幓č«ę
@zh-hant
2001幓č«ę
@zh-hk
2001幓č«ę
@zh-mo
2001幓č«ę
@zh-tw
2001幓č®ŗę
@wuu
name
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
@ast
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
@en
type
label
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
@ast
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
@en
prefLabel
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
@ast
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
@en
P2093
P3181
P1433
P1476
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
@en
P2093
P304
P3181
P356
10.1016/S0896-6273(01)00339-7
P407
P577
2001-07-19T00:00:00Z