A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of and Opioid Receptor Hetero-oligomers
about
Receptor heteromerization and drug discovery.Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesMarked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptorsOpioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesicsAntibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and functionOpioid receptors: toward separation of analgesic from undesirable effectsAnti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonismReceptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimersDirect interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling.Dominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys.Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat.Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.In vivo opioid receptor heteromerization: where do we stand?Prolonged morphine treatment alters δ opioid receptor post-internalization traffickingLigand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for BiodiversityHeteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor traffickingTrafficking of the follitropin receptor.mRNA transcript diversity creates new opportunities for pharmacological intervention.Regulation of G protein-coupled receptor trafficking.Secretin receptor oligomers form intracellularly during maturation through receptor core domains.Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization.Molecular Pharmacology of δ-Opioid Receptors.Receptor and channel heteromers as pain targets.Mu opioids and their receptors: evolution of a concept.Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.G Protein-Coupled Receptor Heteromers.Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord.Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuseG protein-coupled receptors: walking hand-in-hand, talking hand-in-hand?Opioid receptor trafficking and signaling: what happens after opioid receptor activation?Functional relevance of μ-δ opioid receptor heteromerization: a role in novel signaling and implications for the treatment of addiction disorders: from a symposium on new concepts in mu-opioid pharmacology.Evidence from basic research for opioid combinations.Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional ReceptorsThe design of multitarget ligands for chronic and neuropathic pain.Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.The Follitropin Receptor: Matching Structure and Function.Agonists at the δ-opioid receptor modify the binding of µ-receptor agonists to the µ-δ receptor hetero-oligomer.
P2860
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P2860
A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of and Opioid Receptor Hetero-oligomers
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A Role for the Distal Carboxyl ...... ioid Receptor Hetero-oligomers
@ast
A Role for the Distal Carboxyl ...... ioid Receptor Hetero-oligomers
@en
type
label
A Role for the Distal Carboxyl ...... ioid Receptor Hetero-oligomers
@ast
A Role for the Distal Carboxyl ...... ioid Receptor Hetero-oligomers
@en
prefLabel
A Role for the Distal Carboxyl ...... ioid Receptor Hetero-oligomers
@ast
A Role for the Distal Carboxyl ...... ioid Receptor Hetero-oligomers
@en
P2093
P2860
P356
P1476
A Role for the Distal Carboxyl ...... ioid Receptor Hetero-oligomers
@en
P2093
P2860
P304
38478-38488
P356
10.1074/JBC.M505644200
P407
P577
2005-09-13T00:00:00Z