Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
about
ABL tyrosine kinases: evolution of function, regulation, and specificityEvidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosisAllosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activationThe MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repairMultifunctional Abl kinases in health and diseaseThe growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABLStructural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemiaThe lattice as allosteric effector: Structural studies of - and -tubulin clarify the role of GTP in microtubule assemblyE2 interaction and dimerization in the crystal structure of TRAF6A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainCrystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation MechanismTargeting the SH2-Kinase Interface in Bcr-Abl Inhibits LeukemogenesisTwo Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated CortactinMechanisms of drug resistance in kinases.Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activityDynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its ActivityAllosteric interactions between the myristate- and ATP-site of the Abl kinaseModeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug designRoles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functionsThe SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionFluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Functionc-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in SolutionParallel Chemical Protein Synthesis on a Surface Enables the Rapid Analysis of the Phosphoregulation of SH3 Domains.Constitutive Activity in an Ancestral Form of Abl Tyrosine Kinase.Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-capIntramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membranePartial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitorsFunctional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib.Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.Abl N-terminal cap stabilization of SH3 domain dynamicsMechanism and functional significance of Itk autophosphorylation.On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.
P2860
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P2860
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Organization of the SH3-SH2 un ...... of the c-Abl tyrosine kinase.
@ast
Organization of the SH3-SH2 un ...... of the c-Abl tyrosine kinase.
@en
type
label
Organization of the SH3-SH2 un ...... of the c-Abl tyrosine kinase.
@ast
Organization of the SH3-SH2 un ...... of the c-Abl tyrosine kinase.
@en
prefLabel
Organization of the SH3-SH2 un ...... of the c-Abl tyrosine kinase.
@ast
Organization of the SH3-SH2 un ...... of the c-Abl tyrosine kinase.
@en
P2093
P50
P1433
P1476
Organization of the SH3-SH2 un ...... of the c-Abl tyrosine kinase.
@en
P2093
Bhushan Nagar
Jason M Davies
William I Weis
P304
P356
10.1016/J.MOLCEL.2006.01.035
P577
2006-03-01T00:00:00Z