Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.
about
Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticlesGPVI and integrin alphaIIb beta3 signaling in plateletsThe tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosisMegakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet functionThe serine/threonine kinase 33 is present and expressed in palaeognath birds but has become a unitary pseudogene in neognaths about 100 million years agoRhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formationVav3-deficient mice exhibit a transient delay in cerebellar developmentA role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1)Expression profiling of circulating non-red blood cells in embryonic blood.Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling.Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic stateNonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters.Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation.Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"IL-17A increases ADP-induced platelet aggregation.Vav protein guanine nucleotide exchange factor regulates CD36 protein-mediated macrophage foam cell formation via calcium and dynamin-dependent processes.Rap1-Rac1 circuits potentiate platelet activationRole for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregationPreferential protection of protein interaction network hubs in yeast: evolved functionality of genetic redundancy.Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation.A guide to murine platelet structure, function, assays, and genetic alterations.Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.Compartmentalization of ITAM and integrin signaling by adapter molecules.Platelet integrins and immunoreceptors.Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.The future of glycoprotein VI as an antithrombotic target.Rho GTPases in platelet functionTspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets.Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signalingThe role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation.
P2860
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P2860
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Vav1 and vav3 have critical bu ...... atelet activation by collagen.
@ast
Vav1 and vav3 have critical bu ...... atelet activation by collagen.
@en
type
label
Vav1 and vav3 have critical bu ...... atelet activation by collagen.
@ast
Vav1 and vav3 have critical bu ...... atelet activation by collagen.
@en
prefLabel
Vav1 and vav3 have critical bu ...... atelet activation by collagen.
@ast
Vav1 and vav3 have critical bu ...... atelet activation by collagen.
@en
P2093
P2860
P50
P356
P1476
Vav1 and vav3 have critical bu ...... latelet activation by collagen
@en
P2093
Andrew C Pearce
Daniel D Billadeau
Elena Vigorito
P2860
P304
53955-53962
P356
10.1074/JBC.M410355200
P407
P577
2004-09-27T00:00:00Z