Grb2 regulates internalization of EGF receptors through clathrin-coated pits. - Wikidata - awgldk - TriplyDB

Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

http://www.wikidata.org/entity/Q30164836

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Threshold-controlled ubiquitination of the EGFR directs receptor fate Novel RING E3 ubiquitin ligases in breast cancer Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1 Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells Inhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR Signaling The Chlamydia pneumoniae invasin protein Pmp21 recruits the EGF receptor for host cell entry Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers Endocytosis and Trafficking of Natriuretic Peptide Receptor-A: Potential Role of Short Sequence Motifs Weak binding to E3 ubiquitin ligase c-Cbl increases EGFRvA protein stability The Cbl interactome and its functions P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances Endocytosis and signalling: intertwining molecular networks Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer's disease-like scenario.SPIN90 knockdown attenuates the formation and movement of endosomal vesicles in the early stages of epidermal growth factor receptor endocytosis.Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation.Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits Cell migration is regulated by platelet-derived growth factor receptor endocytosis Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells.Endosomal targeting of MEK2 requires RAF, MEK kinase activity and clathrin-dependent endocytosis Invasive and adherent bacterial pathogens co-Opt host clathrin for infection.Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis.CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor.Phosphatidic acid plays a regulatory role in clathrin-mediated endocytosis.

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P2860

Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

http://www.wikidata.org/entity/Q30164836

description

2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

@zh-hk

2003年論文

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2003年論文

@zh-tw

2003年论文

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name

Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

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type

label

Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

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prefLabel

Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

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MBC.E02-08-0532

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Molecular Biology of the Cell

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits.

@en

P2093

Alexander Sorkin

http://www.w3.org/2001/XMLSchema#string

Andriy Marusyk

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Fangtian Huang

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Xuejun Jiang

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P2860

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells

Cell signaling by receptor tyrosine kinases

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

Shc mediates ligand-induced internalization of epidermal growth factor receptors

Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

Role of Grb2 in EGF-stimulated EGFR internalization.

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

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858-870

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scholarly article

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10.1091/MBC.E02-08-0532

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3

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14

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2003-03-01T00:00:00Z

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12631709

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151565

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