The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
about
Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoidsThe cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives.HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain.PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes.
P2860
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P2860
The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
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2000年論文
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2000年论文
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The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
@ast
The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
@en
type
label
The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
@ast
The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
@en
prefLabel
The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
@ast
The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
@en
P2093
P2860
P356
P1433
P1476
The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203955
P407
P577
2000-11-01T00:00:00Z
P5875
P6179
1047740454