The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. - Wikidata - awgldk - TriplyDB

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

http://www.wikidata.org/entity/Q34189442

about

Redox signaling regulated by electrophiles and reactive sulfur species The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis.Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy Proresolving lipid mediators and mechanisms in the resolution of acute inflammation 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ as an electrophilic mediator.Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration.Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration.Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.Formation and signaling actions of electrophilic lipids Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438)Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion.Detection of electrophile-sensitive proteins.Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives.Regulation of redox signalling by an electrophilic cyclic nucleotide.Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function.Physiological and Pathological Roles of 15-Deoxy-Δ12,14-Prostaglandin J2 in the Central Nervous System and Neurological Diseases.15-Deoxy-Δ12,14-Prostaglandin J2 Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue.PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages.15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma.Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway.The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes.Functional specificity of ras isoforms: so similar but so different.Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione.The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action.15-Deoxy-Δ12,14-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2.Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats.

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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

http://www.wikidata.org/entity/Q34189442

description

2003 nî lūn-bûn

@nan

2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2003 թվականի ապրիլին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@ast

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@en

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@nl

type

label

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@ast

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@en

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@nl

prefLabel

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@ast

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@en

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

P1476

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

@en

P2093

Antonio Castrillo

http://www.w3.org/2001/XMLSchema#string

Dolores Pérez-Sala

http://www.w3.org/2001/XMLSchema#string

F Javier Cañada

http://www.w3.org/2001/XMLSchema#string

Jose Luis Oliva

http://www.w3.org/2001/XMLSchema#string

José M Rojas

http://www.w3.org/2001/XMLSchema#string

Lisardo Boscá

http://www.w3.org/2001/XMLSchema#string

Natalia Martínez

http://www.w3.org/2001/XMLSchema#string

P2860

Rho GTPases and the actin cytoskeleton

Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation

The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.

A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma.

Novel aspects of Ras proteins biology: regulation and implications.

Understanding Ras: 'it ain't over 'til it's over'.

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.

15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit.

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4772-4777

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scholarly article

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10.1073/PNAS.0735842100

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8

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100

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10813710

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12684535

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153631

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