Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.
about
The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesisTight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domainsGasp, a Grb2-associating protein, is critical for positive selection of thymocytesInteraction of Shc with Grb2 regulates association of Grb2 with mSOSThe role of water molecules in the binding of class I and II peptides to the SH3 domain of the Fyn tyrosine kinaseRegions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligandsMolecular cloning and characterization of growth factor receptor bound-protein in Clonorchis sinensis.A Conserved residue in the yeast Bem1p SH3 domain maintains the high level of binding specificity required for function.Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteinsMultiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.Hepatocyte growth factor/scatter factor-induced intracellular signalling.Physical modulation of intracellular signaling processes by locational regulation.Gγ recruitment systems specifically select PPI and affinity-enhanced candidate proteins that interact with membrane protein targetsLAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer modelGrb2, a double-edged sword of receptor tyrosine kinase signalingThe adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptorMost yeast SH3 domains bind peptide targets with high intrinsic specificity.
P2860
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P2860
Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.
description
1994 nî lūn-bûn
@nan
1994 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Binding of the Grb2 SH2 domain ...... s for Sos proline-rich motifs.
@ast
Binding of the Grb2 SH2 domain ...... s for Sos proline-rich motifs.
@en
type
label
Binding of the Grb2 SH2 domain ...... s for Sos proline-rich motifs.
@ast
Binding of the Grb2 SH2 domain ...... s for Sos proline-rich motifs.
@en
prefLabel
Binding of the Grb2 SH2 domain ...... s for Sos proline-rich motifs.
@ast
Binding of the Grb2 SH2 domain ...... s for Sos proline-rich motifs.
@en
P2093
P2860
P1433
P1476
Binding of the Grb2 SH2 domain ...... s for Sos proline-rich motifs.
@en
P2093
P2860
P304
P407
P577
1994-09-01T00:00:00Z