Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
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NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptideMutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 functionIdentification of an actin-binding site in p47phox an organizer protein of NADPH oxidaseActivation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phoxBinding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interactionEffects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domainsTandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulationEffects of Anaplasma phagocytophila on NADPH oxidase components in human neutrophils and HL-60 cells.Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidasesPhosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activationActivation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration.Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.Full-length p40phox structure suggests a basis for regulation mechanism of its membrane bindingThe phox homology (PX) domain protein interaction network in yeast.Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phoxDeletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activityCryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesActivation and assembly of the NADPH oxidase: a structural perspectivep40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domainPhosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activityNaphthalenesulphonamides block neutrophil superoxide production by intact cells and in a cell-free system: is myosin light chain kinase responsible for these effects?Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidaseTrimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidaseIn silico phosphorylation of the autoinhibited form of p47(phox): insights into the mechanism of activationp47phox molecular activation for assembly of the neutrophil NADPH oxidase complex.Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phosphSolution structure of the tandem Src homology 3 domains of p47phox in an autoinhibited form.Properties of phagocyte NADPH oxidase p47-phox mutants with unmasked SH3 (Src homology 3) domains: full reconstitution of oxidase activity in a semi-recombinant cell-free system lacking arachidonic acidThe adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase.Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox).Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex.Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking".Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in C terminally truncated forms. Implication for regulatory Src homology 3 domain-mediated interactions.Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activation.NADPH oxidase activity is independent of p47phox in vitro.Assembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidase.Involvement of p40phox in activation of phagocyte NADPH oxidase through association of its carboxyl-terminal, but not its amino-terminal, with p67phoxInteractions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phox.
P2860
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P2860
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
@ast
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
@en
type
label
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
@ast
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
@en
prefLabel
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
@ast
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
@en
P2093
P2860
P356
P1476
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
@en
P2093
Fukumaki Y
Minakami S
Sumimoto H
Takeshige K
P2860
P304
P356
10.1073/PNAS.91.12.5345
P407
P577
1994-06-01T00:00:00Z