Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements.
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Mechanisms of change in gene copy numberA mechanism of gene amplification driven by small DNA fragments.DNA secondary structure at chromosomal fragile sites in human disease.Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers.The role of DNA breaks in genomic instability and tumorigenesis.How a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells.Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability.Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas.Nurturing the genome: A-type lamins preserve genomic stability.Tumor hypoxia as a driving force in genetic instability.Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironmentGene amplification in human cells knocked down for RAD54Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer.Patterns and mechanisms of structural variations in human cancer
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Q22122003-39BE238F-C0C3-4159-8612-75E16570E4AFQ27930879-01083866-FC4B-407B-AD86-64679E6A30C1Q30300009-92893DD3-85FA-4AD0-806C-3C688B06D5BCQ34364066-22BDF164-2305-48C1-BEDA-5345A113AFA1Q35170919-B4B5AB7D-1493-4DC7-A5A4-C059AEC43979Q35213126-7149B8B7-29B8-4C45-A1CD-45B88375498BQ35790060-5141E5F5-F78A-475C-9C58-03C773AFD94FQ36532727-BBA07288-DD5F-48B3-8BC9-A554C7CE5A76Q37388726-E026499B-0035-4EB0-9AA0-1CCE6926D2F2Q37843627-82520FC9-E8CB-412F-A834-6A289686A7C9Q38155002-16EA99CA-6CD6-471D-8035-4DE9D9EB3191Q38468410-33C18025-7699-4C36-8B10-C26288FDED59Q42112893-8A58FD75-A248-4A16-9F29-AB725E114096Q45001863-35CFD027-80EF-42CF-B45A-8946480567DCQ58797497-7DB653C9-5ACF-4218-867B-5E84368E8B1F
P2860
Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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name
Induction of multiple double-s ...... er chromosomal rearrangements.
@en
Induction of multiple double-s ...... er chromosomal rearrangements.
@nl
type
label
Induction of multiple double-s ...... er chromosomal rearrangements.
@en
Induction of multiple double-s ...... er chromosomal rearrangements.
@nl
prefLabel
Induction of multiple double-s ...... er chromosomal rearrangements.
@en
Induction of multiple double-s ...... er chromosomal rearrangements.
@nl
P2093
P2860
P356
P1433
P1476
Induction of multiple double-s ...... er chromosomal rearrangements.
@en
P2093
Arnaud Coquelle
Bernard Dutrillaux
Lorène Rozier
Michelle Debatisse
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205880
P407
P577
2002-10-01T00:00:00Z