Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration - Wikidata - awgldk - TriplyDB

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

http://www.wikidata.org/entity/Q30373366

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Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe.Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases.Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.Alpha-synuclein propagation: New insights from animal models.Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.Failing as doorman and disc jockey at the same time: Amygdalar dysfunction in Parkinson's disease.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type Parkinson's disease and prion disease: Straining the comparison.Targeting α-synuclein: Therapeutic options.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.How strong is the evidence that Parkinson's disease is a prion disorder?Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.Calcium and Parkinson's disease.Alpha-synuclein and iron: two keys unlocking Parkinson's disease.Potential Modes of Intercellular α-Synuclein Transmission.The role of nonhuman primate models in the development of cell-based therapies for Parkinson's disease.Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.Animal models of α-synucleinopathy for Parkinson disease drug development.Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity.Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal.Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression.α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

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P2860

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

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Neurobiology of Disease

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Caryl E Sortwell

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Christopher J Kemp

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Fredric P Manfredsson

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Sheila Fleming

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P2860

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Staging of brain pathology related to sporadic Parkinson's disease

Alpha-synuclein and neurodegenerative diseases

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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10.1016/J.NBD.2015.06.003

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Nicholas M. Kanaan

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