Secretion efficiency in Saccharomyces cerevisiae of bovine pancreatic trypsin inhibitor mutants lacking disulfide bonds is correlated with thermodynamic stability.
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Applications of Yeast Surface Display for Protein EngineeringInvestigating the effects of double mutation C30A/C75A on onconase structure: Studies at atomic resolutionStable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation ActivityExploring sequence characteristics related to high-level production of secreted proteins in Aspergillus nigerPressure response of protein backbone structure. Pressure-induced amide 15N chemical shifts in BPTI.Screening for stable mutants with amino acid pairs substituted for the disulfide bond between residues 14 and 38 of bovine pancreatic trypsin inhibitor (BPTI).Cellular quality control screening to identify amino acid pairs for substituting the disulfide bonds in immunoglobulin fold domains.Biased mutagenesis in the N-terminal region by degenerate oligonucleotide gene shuffling enhances secretory expression of barley alpha-amylase 2 in yeast.Stability and CDR composition biases enrich binder functionality landscapes.Toward development of a screen to identify randomly encoded, foldable sequences.Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeastTheoretical and experimental study of the D2194G mutation in the C2 domain of coagulation factor V.Optimizing recombinant antibodies for intracellular function using hitchhiker-mediated survival selectionFolding, quality control, and secretion of pancreatic ribonuclease in live cellsFunctional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.Photo-fermentative bacteria aggregation triggered by L-cysteine during hydrogen production.Oxidative folding and N-terminal cyclization of onconase.Biophysical properties of the clinical-stage antibody landscape.Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae.The safety dance: biophysics of membrane protein folding and misfolding in a cellular contextDegradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control.Cell-cell fusion induced by the avian reovirus membrane fusion protein is regulated by protein degradationMutational study on the roles of disulfide bonds in the beta-subunit of gastric H+,K+-ATPase.Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22.Function and stability of human transcobalamin II: role of intramolecular disulfide bonds C98-C291 and C147-C187.Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display.Secretion and properties of a hybrid Kluyveromyces lactis-Aspergillus niger beta-galactosidase.Genetic selection for enhanced folding in vivo targets the Cys14-Cys38 disulfide bond in bovine pancreatic trypsin inhibitor.A single disulfide bond restores thermodynamic and proteolytic stability to an extensively mutated protein.Mutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha.Endowing human pancreatic ribonuclease with toxicity for cancer cells.Engineering-enhanced protein secretory expression in yeast with application to insulin.Protein folding stability can determine the efficiency of escape from endoplasmic reticulum quality control.The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants.Fusion of an intact secretory protein permits a misfolded protein to exit from the endoplasmic reticulum in yeastConformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
P2860
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P2860
Secretion efficiency in Saccharomyces cerevisiae of bovine pancreatic trypsin inhibitor mutants lacking disulfide bonds is correlated with thermodynamic stability.
description
1998 nî lūn-bûn
@nan
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Secretion efficiency in Saccha ...... with thermodynamic stability.
@ast
Secretion efficiency in Saccha ...... with thermodynamic stability.
@en
type
label
Secretion efficiency in Saccha ...... with thermodynamic stability.
@ast
Secretion efficiency in Saccha ...... with thermodynamic stability.
@en
prefLabel
Secretion efficiency in Saccha ...... with thermodynamic stability.
@ast
Secretion efficiency in Saccha ...... with thermodynamic stability.
@en
P2093
P356
P1433
P1476
Secretion efficiency in Saccha ...... with thermodynamic stability.
@en
P2093
Kowalski JM
Wittrup KD
P304
P356
10.1021/BI9722397
P407
P577
1998-02-01T00:00:00Z