Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts - Wikidata - awgldk - TriplyDB

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

http://www.wikidata.org/entity/Q30436718

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Structural basis of substrate discrimination and integrin binding by autotaxin Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations Characterization of a sphingosine 1-phosphate receptor antagonist prodrug Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.LPA receptor signaling: pharmacology, physiology, and pathophysiology.Stat3 mediates expression of autotaxin in breast cancer Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases Ligand-based autotaxin pharmacophore models reflect structure-based docking results.Constitutive and Inducible Expression of Invasion-related Factors in PC-3 Prostate Cancer Cells.Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin.Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis.Mesenchymal stem cells increase proliferation but do not change quiescent state of osteosarcoma cells: Potential implications according to the tumor resection status Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation.Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells.Therapeutic potentials of ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-5'-nucleotidase, and alkaline phosphatase inhibitors.The role and therapeutic potential of the autotaxin-lysophosphatidate signalling axis in breast cancer.Meaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns.Lysophosphatidic acid activates the RhoA and NF-κB through Akt/IκBα signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation.Osteoblast-osteoclast interactions.Autotaxin inhibitors: a patent review (2012-2016).Targeting Platelets for the Treatment of Cancer.Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis.Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation.The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice.Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis.Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.Necessity of lysophosphatidic acid receptor 1 for development of arthritis.Lysophosphatidic acid stimulates osteoclast fusion through OC-STAMP and P2X7 receptor signaling.

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P2860

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

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2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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Cancer cell expression of auto ...... dent activation of osteoclasts

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Blandine Deux

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Claire-Marie Serre

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Estelle Wannecq

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Silvia Jansen

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P2860

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases

Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase

Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells

Expression, regulation and function of autotaxin in thyroid carcinomas

G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers

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Philippe Clézardin

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42372775

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