Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

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Ligand-based autotaxin pharmacophore models reflect structure-based docking results.Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.Autotaxin inhibitors: a patent review (2012-2016).

P2860

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P2860

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

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http://www.wikidata.org/entity/Q41861974

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2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

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type

Item

label

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

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prefLabel

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

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P1476

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

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P2093

Abby L Parrill

http://www.w3.org/2001/XMLSchema#string

Daniel L Baker

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P2860

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression

L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin

Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin

Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

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1619-1625

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scholarly article

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10.1517/13543776.2010.533658

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English

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2010-11-04T00:00:00Z

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47675201

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21047298

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Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

about

P2860

P2860

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932